Signaling through Receptors and Scaffolds: Independent Interactions Reduce Combinatorial Complexity
Abstract
After activation, many receptors and their adaptor proteins act as scaffolds displaying numerous docking sites and engaging multiple targets. The consequent assemblage of a variety of protein complexes results in a combinatorial increase in the number of feasible molecular species presenting different states of a receptor-scaffold signaling module. Tens of thousands of such microstates emerge even for the initial signal propagation events,...
Paper Details
Title
Signaling through Receptors and Scaffolds: Independent Interactions Reduce Combinatorial Complexity
Published Date
Aug 1, 2005
Journal
Volume
89
Issue
2
Pages
951 - 966
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Notes
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