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Avian metapneumovirus (AMPV) attachment protein involvement in probable virus evolution concurrent with mass live vaccine introduction

Published on Nov 1, 2010in Veterinary Microbiology2.79
· DOI :10.1016/j.vetmic.2010.04.014
Mattia Cecchinato12
Estimated H-index: 12
(UNIPD: University of Padua),
E. Catelli12
Estimated H-index: 12
(UNIBO: University of Bologna)
+ 4 AuthorsC. J. Naylor17
Estimated H-index: 17
(University of Liverpool)
Abstract
Avian metapneumoviruses detected in Northern Italy between 1987 and 2007 were sequenced in their fusion (F) and attachment (G) genes together with the same genes from isolates collected throughout western European prior to 1994. Fusion protein genes sequences were highly conserved while G protein sequences showed much greater heterogeneity. Phylogenetic studies based on both genes clearly showed that later Italian viruses were significantly different to all earlier virus detections, including early detections from Italy. Furthermore a serine residue in the G proteins and lysine residue in the fusion protein were exclusive to Italian viruses, indicating that later viruses probably arose within the country and the notion that these later viruses evolved from earlier Italian progenitors cannot be discounted. Biocomputing analysis applied to F and G proteins of later Italian viruses predicted that only G contained altered T cell epitopes. It appears likely that Italian field viruses evolved in response to selection pressure from vaccine induced immunity.
  • References (36)
  • Citations (34)
References36
Newest
#1E. Catelli (UNIBO: University of Bologna)H-Index: 12
#2C. Lupini (UNIBO: University of Bologna)H-Index: 3
Last.C. J. Naylor (University of Liverpool)H-Index: 17
view all 6 authors...
#1Miranda de Graaf (EUR: Erasmus University Rotterdam)H-Index: 24
#2Albert D. M. E. Osterhaus (EUR: Erasmus University Rotterdam)H-Index: 112
Last.Edward C. Holmes (PSU: Pennsylvania State University)H-Index: 109
view all 4 authors...
#1Ademola A. Owoade (UI: University of Ibadan)H-Index: 11
#2M. F. Ducatez (HKU: University of Hong Kong)H-Index: 2
Last.C. P. Muller (HKU: University of Hong Kong)H-Index: 2
view all 7 authors...
#1Christian Cole (Dund.: University of Dundee)H-Index: 18
#2Jonathan D. Barber (Dund.: University of Dundee)H-Index: 4
Last.Geoffrey J. Barton (Dund.: University of Dundee)H-Index: 58
view all 3 authors...
#1Mark A. Larkin (EMBL-EBI: European Bioinformatics Institute)H-Index: 2
#2Gordon Blackshields (EMBL-EBI: European Bioinformatics Institute)H-Index: 9
Last.Rodrigo Lopez (EMBL-EBI: European Bioinformatics Institute)H-Index: 44
view all 13 authors...
Cited By34
Newest
#1Claire M. Jardine (U of G: University of Guelph)H-Index: 14
#2E. J. Parmley (U of G: University of Guelph)H-Index: 1
Last.Davor Ojkic (U of G: University of Guelph)H-Index: 21
view all 5 authors...
#1Claudia Maria Tucciarone (UNIPD: University of Padua)H-Index: 5
#2Giovanni Franzo (UNIPD: University of Padua)H-Index: 10
Last.Mattia Cecchinato (UNIPD: University of Padua)H-Index: 12
view all 10 authors...
#1Haixia Hu (SWU: Southwest University)H-Index: 3
#2Jason P. Roth (Merial)H-Index: 3
Last.Qingzhong Yu (USDA: United States Department of Agriculture)H-Index: 13
view all 4 authors...
#1V. Felice (UNIBO: University of Bologna)H-Index: 2
#2Giovanni Franzo (UNIPD: University of Padua)H-Index: 10
Last.C. Lupini (UNIBO: University of Bologna)H-Index: 3
view all 10 authors...
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