Match!

Avian metapneumovirus (AMPV) attachment protein involvement in probable virus evolution concurrent with mass live vaccine introduction

Published on Nov 1, 2010in Veterinary Microbiology2.791
· DOI :10.1016/j.vetmic.2010.04.014
Mattia Cecchinato13
Estimated H-index: 13
(UNIPD: University of Padua),
Elena Catelli13
Estimated H-index: 13
(UNIBO: University of Bologna)
+ 4 AuthorsClive J. Naylor18
Estimated H-index: 18
(University of Liverpool)
Abstract
Avian metapneumoviruses detected in Northern Italy between 1987 and 2007 were sequenced in their fusion (F) and attachment (G) genes together with the same genes from isolates collected throughout western European prior to 1994. Fusion protein genes sequences were highly conserved while G protein sequences showed much greater heterogeneity. Phylogenetic studies based on both genes clearly showed that later Italian viruses were significantly different to all earlier virus detections, including early detections from Italy. Furthermore a serine residue in the G proteins and lysine residue in the fusion protein were exclusive to Italian viruses, indicating that later viruses probably arose within the country and the notion that these later viruses evolved from earlier Italian progenitors cannot be discounted. Biocomputing analysis applied to F and G proteins of later Italian viruses predicted that only G contained altered T cell epitopes. It appears likely that Italian field viruses evolved in response to selection pressure from vaccine induced immunity.
  • References (36)
  • Citations (37)
📖 Papers frequently viewed together
20103.27Vaccine
6 Authors (Elena Catelli, ..., Clive J. Naylor)
37 Citations
20063.27Vaccine
5 Authors (Elena Catelli, ..., Clive J. Naylor)
60 Citations
136 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References36
Newest
Abstract The avian Metapneumovirus (aMPV) causes an economically important acute respiratory disease in turkeys (turkey rhinotracheitis, TRT). While antibodies were shown to be insufficient for protection against aMPV-infection, the role of T-lymphocytes in the control of aMPV-infection is not clear. In this study we investigated the role of T-lymphocytes in aMPV-pathogenesis in a T-cell-suppression model in turkeys. T-cell-intact turkeys and turkeys partly depleted of functional CD4 + and CD8 +...
8 CitationsSource
#1Elena Catelli (UNIBO: University of Bologna)H-Index: 13
#2C. Lupini (UNIBO: University of Bologna)H-Index: 3
Last. Clive J. Naylor (University of Liverpool)H-Index: 18
view all 6 authors...
37 CitationsSource
The avian metapneumovirus (aMPV) is the causative agent of an acute respiratory disease in turkeys, which causes considerable economic losses to the poultry industry. Currently attenuated live and inactivated vaccines are widely used to control the disease, but vaccine breaks are frequently observed. For improvement of current vaccination strategies it is necessary to gain enhanced knowledge of the immune mechanisms against aMPV infection. Field observations suggest that vaccine-induced aMPV-spe...
12 CitationsSource
#1Miranda de Graaf (EUR: Erasmus University Rotterdam)H-Index: 25
#2Albert D. M. E. Osterhaus (EUR: Erasmus University Rotterdam)H-Index: 113
Last. Edward C. Holmes (PSU: Pennsylvania State University)H-Index: 113
view all 4 authors...
Human (HMPV) and avian (AMPV) metapneumoviruses are closely related viruses that cause respiratory tract illnesses in humans and birds, respectively. Although HMPV was first discovered in 2001, retrospective studies have shown that HMPV has been circulating in humans for at least 50 years. AMPV was first isolated in the 1970s, and can be classified into four subgroups, A–D. AMPV subgroup C is more closely related to HMPV than to any other AMPV subgroup, suggesting that HMPV has emerged from AMPV...
69 CitationsSource
#1A. A. Owoade (UI: University of Ibadan)H-Index: 11
#2M. F. Ducatez (HKU: University of Hong Kong)H-Index: 2
Last. C. P. Muller (HKU: University of Hong Kong)H-Index: 2
view all 7 authors...
Abstract In order to detect and characterize avian metapneumovirus, organs or swabs were collected from 697 chicken and 110 turkeys from commercial farms in Southwestern Nigeria and from 107 chickens from live bird markets in Southeastern China. In Nigeria, 15% and 6% of the chicken and turkey samples, respectively, and 39% of the chicken samples from China, were positive for aMPV genome by PCR. The sequence of a 400 nt fragment of the attachment protein gene (G gene) revealed the presence of aM...
15 CitationsSource
#1Christian Cole (Dund.: University of Dundee)H-Index: 18
#2Jonathan D. Barber (Dund.: University of Dundee)H-Index: 4
Last. Geoffrey J. Barton (Dund.: University of Dundee)H-Index: 60
view all 3 authors...
Jpred (http://www.compbio.dundee.ac.uk/jpred) is a secondary structure prediction server powered by the Jnet algorithm. Jpred performs over 1000 predictions per week for users in more than 50 countries. The recently updated Jnet algorithm provides a three-state (α-helix, β-strand and coil) prediction of secondary structure at an accuracy of 81.5%. Given either a single protein sequence or a multiple sequence alignment, Jpred derives alignment profiles from which predictions of secondary structur...
1,262 CitationsSource
#1Roger Ling (Warw.: University of Warwick)H-Index: 9
#2Sabrina Sinkovic (Warw.: University of Warwick)H-Index: 1
Last. Andrew J. Easton (Warw.: University of Warwick)H-Index: 39
view all 6 authors...
Subgroup A avian metapneumoviruses lacking either the SH or G gene or the M2-2 open reading frame were generated by using a reverse-genetics approach. The growth properties of these viruses were studied in vitro and in vivo in their natural host. Deletion of the SH gene alone resulted in the generation of a syncytial-plaque phenotype and this was reversed by the introduction of the SH gene from a subgroup B, but not a subgroup C, virus. Infected turkeys were assessed for antibody production and ...
27 CitationsSource
#1M.A. Larkin (EMBL-EBI: European Bioinformatics Institute)H-Index: 1
#2Gordon Blackshields (EMBL-EBI: European Bioinformatics Institute)H-Index: 10
Last. Desmond G. Higgins (EMBL-EBI: European Bioinformatics Institute)H-Index: 55
view all 13 authors...
Summary: The Clustal W and Clustal X multiple sequence alignment programs have been completely rewritten in C++. This will facilitate the further development of the alignment algorithms in the future and has allowed proper porting of the programs to the latest versions of Linux, Macintosh and Windows operating systems. Availability: The programs can be run on-line from the EBI web server: http://www.ebi.ac.uk/tools/clustalw2. The source code and executables for Windows, Linux and Macintosh compu...
18.6k CitationsSource
#1Jorge Luis Chacón (USP: University of São Paulo)H-Index: 9
#2Paulo Eduardo Brandão (USP: University of São Paulo)H-Index: 18
Last. Antonio José Piantino Ferreira (USP: University of São Paulo)H-Index: 24
view all 5 authors...
Subtype B avian metapneumovirus (aMPV) was isolated and detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in Brazilian commercial laying chicken flocks with no history of vaccination against aMPV and presenting respiratory signs and decreased egg production. RT-PCR results from samples from three affected flocks revealed that the three isolates were subtype B. Partial sequence analysis of the G glycoprotein gene confirmed that the samples belonged to subtype B and were not of ...
10 CitationsSource
Abstract Most of the studies regarding the immunopathogenesis of avian Metapneumovirus (aMPV) have been done with subtype C of aMPV. Not much is known about the immunopathogenesis of aMPV subtypes A and B in turkeys. Specifically, local immune reactions have not been investigated yet. We conducted two experiments in commercial turkeys. We investigated local and systemic humoral and cell mediated immune reactions following infection with an attenuated vaccine strain of aMPV subtype B (Experiment ...
24 CitationsSource
Cited By37
Newest
#1David L. SuarezH-Index: 63
#2Patti J. MillerH-Index: 24
Last. Silke RautenschleinH-Index: 20
view all 5 authors...
9 CitationsSource
#1E. BayraktarH-Index: 1
#2Sajid Umar (Pir Mehr Ali Shah Arid Agriculture University)H-Index: 7
Last. Huseyin YilmazH-Index: 14
view all 5 authors...
The Turkish poultry industry has rapidly developed in the last decade. Viral pathogens continue to threaten the industry, causing economic losses worldwide, including Turkey. At present, infectious...
Source
#1Giovanni Franzo (UNIPD: University of Padua)H-Index: 11
#2Matteo Legnardi (UNIPD: University of Padua)H-Index: 4
Last. Mattia Cecchinato (UNIPD: University of Padua)H-Index: 13
view all 6 authors...
Despite the fact that vaccine resistance has been typically considered a rare phenomenon, some episodes of vaccine failure have been reported with increasing frequency in intensively-raised livestock. Infectious bronchitis virus (IBV) is a widespread avian coronavirus, whose control relies mainly on extensive vaccine administration. Unfortunately, the continuous emergence of new vaccine-immunity escaping variants prompts the development of new vaccines. In the present work, a molecular epidemiol...
Source
#1Marianna Andreopoulou (Leipzig University)
#2Giovanni Franzo (UNIPD: University of Padua)H-Index: 11
view all 7 authors...
Source
#1David A. Kennedy (PSU: Pennsylvania State University)H-Index: 9
#2Andrew F. Read (PSU: Pennsylvania State University)H-Index: 70
Vaccines and antimicrobial drugs both impose strong selection for resistance. Yet only drug resistance is a major challenge for 21st century medicine. Why is drug resistance ubiquitous and not vaccine resistance? Part of the answer is that vaccine resistance is far less likely to evolve than drug resistance. But what happens when vaccine resistance does evolve? We review six putative cases. We find that in contrast to drug resistance, vaccine resistance is harder to detect and harder to confirm ...
4 CitationsSource
#1E. Bayraktar (CEVA Logistics)H-Index: 1
#2S. Umar (Istanbul University)H-Index: 1
Last. Huseyin Yilmaz (Istanbul University)H-Index: 14
view all 10 authors...
Viral respiratory diseases including avian metapneumovirus (aMPV) have a significant economic impact on poultry industries. The frequency and genotype diversity of aMPV in Turkish broiler flocks is not known at present. The aim of this study was to report the first molecular identification and phylogeny of aMPV which is circulating in Turkish broiler flocks. Trachea tissue samples and tracheal swabs were collected from 110 broiler flocks distributed in different geographical regions in Turkey be...
1 CitationsSource
#1Claire M. Jardine (U of G: University of Guelph)H-Index: 15
#2E. J. Parmley (U of G: University of Guelph)H-Index: 1
Last. Davor Ojkic (U of G: University of Guelph)H-Index: 22
view all 5 authors...
3 CitationsSource
#1Sung J. Yoo (Konkuk University)H-Index: 5
#2Taeyong Kwon (Konkuk University)H-Index: 4
Last. Young S. Lyoo (Konkuk University)H-Index: 13
view all 7 authors...
Modified live vaccines (MLVs) based on genotype 1 strains, particularly C‐strain, have been used to prevent and control classical swine fever virus (CSFV) worldwide. Nevertheless, a shift in the predominant CSFV strains circulating in the field from genotype 1 or 3 to genotype 2 is seen. Genotype 2 is genetically distant from the vaccine strains and was recently reported during outbreaks after vaccine failure; this has raised concerns that vaccination has influenced viral evolution. In Korea in ...
5 CitationsSource
#1Claudia Maria Tucciarone (UNIPD: University of Padua)H-Index: 8
#2Giovanni Franzo (UNIPD: University of Padua)H-Index: 11
Last. Mattia Cecchinato (UNIPD: University of Padua)H-Index: 13
view all 10 authors...
2 CitationsSource
#1Sung J. Yoo (Konkuk University)H-Index: 5
#2Taeyong Kwon (Konkuk University)H-Index: 4
Last. Young S. Lyoo (Konkuk University)H-Index: 13
view all 3 authors...
4 CitationsSource