Metabolic pathways promoting cancer cell survival and growth.
Abstract
Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and...
Paper Details
Title
Metabolic pathways promoting cancer cell survival and growth.
Published Date
Mar 16, 2015
Journal
Volume
17
Issue
4
Pages
351 - 359
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Notes
History