In vivo genome editing using Staphylococcus aureus Cas9

Nature64.80
Volume: 520, Issue: 7546, Pages: 186 - 191
Published: Apr 9, 2015
Abstract
The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its utility for basic research and therapeutic applications that use the highly versatile adeno-associated virus (AAV) delivery vehicle. Here, we characterize six smaller Cas9 orthologues and show that Cas9 from Staphylococcus aureus (SaCas9) can edit the genome with...
Paper Details
Title
In vivo genome editing using Staphylococcus aureus Cas9
Published Date
Apr 9, 2015
Journal
Volume
520
Issue
7546
Pages
186 - 191
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.