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Field avian metapneumovirus evolution avoiding vaccine induced immunity.

Published on Jan 1, 2010in Vaccine3.27
· DOI :10.1016/j.vaccine.2009.10.149
E. Catelli12
Estimated H-index: 12
(UNIBO: University of Bologna),
C. Lupini3
Estimated H-index: 3
(UNIBO: University of Bologna)
+ 3 AuthorsC. J. Naylor17
Estimated H-index: 17
(University of Liverpool)
Cite
Abstract
Live avian metapneumovirus (AMPV) vaccines have largely brought turkey rhinotracheitis (TRT) under control in Europe but unexplained outbreaks still occur. Italian AMPV longitudinal farm studies showed that subtype B AMPVs were frequently detected in turkeys some considerable period after subtype B vaccination. Sequencing showed these to be unrelated to the previously applied vaccine. Sequencing of the entire genome of a typical later isolate showed numerous SH and G protein gene differences when compared to both a 1987 Italian field isolate and the vaccine in common use. Experimental challenge of vaccinated birds with recent virus showed that protection was inferior to that seen after challenge with the earlier 1987 isolate. Field virus had changed in key antigenic regions allowing replication and leading to disease in well vaccinated birds.
  • References (27)
  • Citations (37)
Cite
References27
Newest
Published on Jun 1, 2009in Avian Diseases1.31
Caroline Banet-Noach14
Estimated H-index: 14
(TAU: Tel Aviv University),
Lubov Simanov9
Estimated H-index: 9
+ 2 AuthorsEran Bacharach22
Estimated H-index: 22
(TAU: Tel Aviv University)
Abstract Avian metapneumovirus (aMPV) is a respiratory pathogen and includes four subtypes, which are differentially distributed worldwide. In Israel, two aMPV subtypes, A and B, are cocirculating in an area with a relatively high density of poultry houses. We performed a longitudinal survey in commercial flocks of turkeys and chickens (six and two flocks, respectively) with differing vaccination programs. This study revealed that all monitored flocks were infected by aMPV during the sampling pe...
Published on Dec 1, 2008in Journal of General Virology2.81
Miranda de Graaf24
Estimated H-index: 24
(EUR: Erasmus University Rotterdam),
Albert D. M. E. Osterhaus112
Estimated H-index: 112
(EUR: Erasmus University Rotterdam)
+ 1 AuthorsEdward C. Holmes109
Estimated H-index: 109
(PSU: Pennsylvania State University)
Human (HMPV) and avian (AMPV) metapneumoviruses are closely related viruses that cause respiratory tract illnesses in humans and birds, respectively. Although HMPV was first discovered in 2001, retrospective studies have shown that HMPV has been circulating in humans for at least 50 years. AMPV was first isolated in the 1970s, and can be classified into four subgroups, A–D. AMPV subgroup C is more closely related to HMPV than to any other AMPV subgroup, suggesting that HMPV has emerged from AMPV...
Published on Feb 1, 2008in Journal of General Virology2.81
Roger Ling9
Estimated H-index: 9
(Warw.: University of Warwick),
Sabrina Sinkovic1
Estimated H-index: 1
(Warw.: University of Warwick)
+ 3 AuthorsAndrew J. Easton37
Estimated H-index: 37
(Warw.: University of Warwick)
Subgroup A avian metapneumoviruses lacking either the SH or G gene or the M2-2 open reading frame were generated by using a reverse-genetics approach. The growth properties of these viruses were studied in vitro and in vivo in their natural host. Deletion of the SH gene alone resulted in the generation of a syncytial-plaque phenotype and this was reversed by the introduction of the SH gene from a subgroup B, but not a subgroup C, virus. Infected turkeys were assessed for antibody production and ...
Published on Feb 1, 2008in Virus Research2.74
Abinash Padhi13
Estimated H-index: 13
(TU: University of Tulsa),
Bindhu Verghese8
Estimated H-index: 8
(TU: University of Tulsa)
Abstract Human metapneumovirus (hMPV), a newly discovered virus of the family Paramyxoviridae , has been associated with upper and lower respiratory tract infections in different age groups in many countries. The putative attachment (G) glycoprotein of this virus was previously reported to have shown more extensive nucleotide and deduced amino acid sequence polymorphism than any other genomic regions of this virus, leading to four sub-lineages. Using a maximum likelihood-based codon substitution...
Published on Jun 1, 2007in Journal of General Virology2.81
C. J. Naylor17
Estimated H-index: 17
(University of Liverpool),
Roger Ling9
Estimated H-index: 9
(Warw.: University of Warwick)
+ 2 AuthorsAndrew J. Easton37
Estimated H-index: 37
(Warw.: University of Warwick)
A prototype avian metapneumovirus (AMPV) vaccine (P20) was previously shown to give variable outcomes in experimental trials. Following plaque purification, three of 12 viruses obtained from P20 failed to induce protection against virulent challenge, whilst the remainder retained their protective capacity. The genome sequences of two protective viruses were identical to the P20 consensus, whereas two non-protective viruses differed only in the SH gene transcription termination signal. Northern b...
Published on Oct 1, 2006in Vaccine3.27
E. Catelli12
Estimated H-index: 12
(UNIBO: University of Bologna),
Cecchinato Mattia6
Estimated H-index: 6
(UNIBO: University of Bologna)
+ 2 AuthorsC. J. Naylor17
Estimated H-index: 17
(University of Liverpool)
A live A type avian metapneumovirus (AMPV) vaccine which had been shown to be highly protective and short lived in experimental conditions was found to persist for longer periods in the field and to be associated with disease. Previously other factors such as possible secondary pathogens and management considerations had made it impossible to conclude whether the observed disease was a result of an increase in the vaccine virulence. In this study, an AMPV was isolated from poults on a farm which...
Published on Jun 1, 2005in Avian Pathology1.96
Caroline Banet-Noach14
Estimated H-index: 14
,
Lubov Simanov9
Estimated H-index: 9
,
Shimon Perk9
Estimated H-index: 9
Although the disease associated with the avian metapneumovirus (aMPV) has been described in Israel for more than 20 years and one Israeli isolate was characterized as subtype A, this is the first study investigating the strains circulating in Israel (period 2002 to 2004). Viral RNA was detected by reverse transcription-polymerase chain reaction in 44% of the examined flocks, and one-half of the virus isolation attempts were successful. Characterization showed that 34 non-vaccinated turkey flocks...
Published on Nov 1, 2004in Journal of General Virology2.81
C. J. Naylor17
Estimated H-index: 17
(University of Liverpool),
Paul A. Brown4
Estimated H-index: 4
(University of Liverpool)
+ 4 AuthorsAndrew J. Easton37
Estimated H-index: 37
(Warw.: University of Warwick)
Avian pneumovirus (APV) is a member of the genus Metapneumovirus of the subfamily Pneumovirinae. This study describes the development of a reverse-genetics system for APV. A minigenome system was used to optimize the expression of the nucleoprotein, phosphoprotein, M2 and large polymerase proteins when transfected into Vero cells under the control of the bacteriophage T7 promoter. Subsequently, cDNA was transcribed from the virion RNA to make a full-length antigenome, which was also cloned under...
Published on Nov 1, 2000in Journal of General Virology2.81
M. H. Bäyon-Auboyer5
Estimated H-index: 5
,
Claire Arnauld3
Estimated H-index: 3
+ 1 AuthorsN. Eterradossi23
Estimated H-index: 23
Sequence analysis was performed of all or part of the genes encoding the fusion (F), polymerase (L) and attachment (G) proteins of two French non-A/non-B avian pneumovirus (APV) isolates (Fr/85/1 and Fr/85/2). The two isolates shared at least 99·7% nt and 99·0% aa sequence identity. Comparison with the F genes from subgroup A, subgroup B or Colorado APVs revealed nt and aa identities of 70·0–80·5% and 77·6–97·2%, respectively, with the L gene sharing 76·1% nt and 85·3% aa identity with that of a...
Cited By37
Newest
Published on May 1, 2019in Vaccine3.27
Andrea Laconi3
Estimated H-index: 3
(University of Liverpool),
E. Catelli12
Estimated H-index: 12
(UNIBO: University of Bologna)
+ 1 AuthorsC. J. Naylor17
Estimated H-index: 17
(University of Liverpool)
Abstract Since late ‘80 s Avian metapneumovirus subtype A causes sufficient disease in Europe for commercial companies to have started developing live attenuated vaccines. Here, two of those vaccines were fully consensus sequenced alongside their progenitor field strain (#8544). Sequences comparison shows that the attenuation of field strain #8544 was associated with no common substitutions between the two derived vaccines. This finding suggests that the attenuation of field viruses via serial p...
David A. Kennedy8
Estimated H-index: 8
(PSU: Pennsylvania State University),
Andrew F. Read68
Estimated H-index: 68
(PSU: Pennsylvania State University)
Vaccines and antimicrobial drugs both impose strong selection for resistance. Yet only drug resistance is a major challenge for 21st century medicine. Why is drug resistance ubiquitous and not vaccine resistance? Part of the answer is that vaccine resistance is far less likely to evolve than drug resistance. But what happens when vaccine resistance does evolve? We review six putative cases. We find that in contrast to drug resistance, vaccine resistance is harder to detect and harder to confirm ...
Published on Aug 1, 2018in Transboundary and Emerging Diseases3.55
Claire M. Jardine14
Estimated H-index: 14
(U of G: University of Guelph),
E. J. Parmley1
Estimated H-index: 1
(U of G: University of Guelph)
+ 2 AuthorsDavor Ojkic21
Estimated H-index: 21
(U of G: University of Guelph)
Published on Feb 1, 2018in Poultry Science2.03
Claudia Maria Tucciarone5
Estimated H-index: 5
(UNIPD: University of Padua),
Giovanni Franzo10
Estimated H-index: 10
(UNIPD: University of Padua)
+ 7 AuthorsMattia Cecchinato12
Estimated H-index: 12
(UNIPD: University of Padua)
Published on Dec 1, 2017in Scientific Reports4.01
Haixia Hu3
Estimated H-index: 3
(SWU: Southwest University),
Jason P. Roth3
Estimated H-index: 3
(Merial)
+ 1 AuthorsQingzhong Yu13
Estimated H-index: 13
(USDA: United States Department of Agriculture)
Avian metapneumovirus (AMPV) infects the respiratory and reproductive tracts of domestic poultry, resulting in substantial economic losses for producers. Live attenuated vaccines appear to be the most effective in countries where the disease is prevalent. However, reversion to virulence has been demonstrated in several studies. Therefore, the development of a stable and safe next generation vaccine against the AMPV disease is needed. In the present study, we generated a recombinant Newcastle dis...
Published on Dec 1, 2017in Poultry Science2.03
V. Felice2
Estimated H-index: 2
(UNIBO: University of Bologna),
Giovanni Franzo10
Estimated H-index: 10
(UNIPD: University of Padua)
+ 7 AuthorsC. Lupini3
Estimated H-index: 3
(UNIBO: University of Bologna)
Published on Sep 1, 2017in Avian Diseases1.31
Claudia Maria Tucciarone5
Estimated H-index: 5
,
Marianna Andreopoulou + 3 AuthorsMattia Cecchinato12
Estimated H-index: 12
SUMMARY Avian metapneumovirus (aMPV) is considered a major pathogen for turkeys but its impact on chicken production is still partially neglected, even though it is fully acknowledged as a primary pathogen in chickens as well. The lack of structured diagnostic surveys does not allow a pervasive understanding of aMPV epidemiology. Being that aMPV is almost an everyday challenge for farmers and veterinarians, a more accurate report of its presence should be detailed, posing the basis for a deep an...
Published on Jun 1, 2017in Avian Diseases1.31
Giovanni Franzo10
Estimated H-index: 10
(UNIPD: University of Padua),
Claudia Maria Tucciarone5
Estimated H-index: 5
(UNIPD: University of Padua)
+ 4 AuthorsMattia Cecchinato12
Estimated H-index: 12
(UNIPD: University of Padua)
SUMMARY Avian metapneumovirus (aMPV) represents one of the most prevalent diseases of turkey, especially in combination with other pathogens, and its frequency is also increasing among chickens. Despite this evidence, epidemiologic data are poor and scattered, severely preventing control of the disease even in highly developed areas such as Europe. In the present study, the detection and characterization of an aMPV subtype B strain circulating in a vaccinated but symptomatic Romanian broiler flo...
Published on Dec 1, 2016in Worlds Poultry Science Journal1.36
S. Umar1
Estimated H-index: 1
,
H. Sabir1
Estimated H-index: 1
+ 1 AuthorsS. Subhan1
Estimated H-index: 1
View next paperAvian metapneumovirus (AMPV) attachment protein involvement in probable virus evolution concurrent with mass live vaccine introduction