Topological domains in mammalian genomes identified by analysis of chromatin interactions
Abstract
The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct chromosome territories, and numerous models have been proposed for how chromosomes fold within chromosome territories. These models, however, provide only few mechanistic details about the...
Paper Details
Title
Topological domains in mammalian genomes identified by analysis of chromatin interactions
Published Date
Apr 11, 2012
Journal
Volume
485
Issue
7398
Pages
376 - 380
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Notes
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