A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition
Abstract
Toll-like receptors play important roles in regulating immunity against microbial infections. Toll-like receptor 8 (TLR8) belongs to a subfamily comprising TLR7, TLR8 and TLR9. Human TLR8 mediates anti-viral immunity by recognizing ssRNA viruses, and triggers potent anti-viral and antitumor immune responses upon ligation by synthetic small molecular weight ligands. Interestingly, distinct from human TLR8, mouse TLR8 was not responsive to ligand...
Paper Details
Title
A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition
Published Date
Feb 1, 2010
Journal
Volume
47
Issue
5
Pages
1083 - 1090
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Notes
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