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A small dose of hydrogen peroxide enhances tumor necrosis factor-alpha toxicity in inducing human vascular endothelial cell apoptosis: Reversal with propofol

Published on Jul 1, 2006in Anesthesia & Analgesia3.489
· DOI :10.1213/01.ane.0000221183.02244.80
Tao Luo45
Estimated H-index: 45
,
Zhengyuan Xia32
Estimated H-index: 32
Abstract
We designed the present study to test the hypothesis that oxygen free radicals can enhance tumor necrosis factor (TNF)-α cellular toxicity, which might be reversed by propofol, an anesthetic with antioxidant properties, in human vascular endothelial cell line ECV304. Cultured ECV304 were either not
  • References (29)
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References29
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#1Tao LuoH-Index: 45
#2Zhengyuan XiaH-Index: 32
Last. Xian-Yi LiuH-Index: 3
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We investigated whether propofol can inhibit tumor necrosis factor (TNF)-α-induced apoptosis in cultured human umbilical vein endothelial cells (HUVECs). Isolated HUVECs were cultured in Dulbecco's modified Eagle medium supplemented with 20% bovine calf serum. HUVECs in untreated and propofol control groups were cultured at 37°C for 24.5 h. HUVECs in the TNF treatment groups were initially cultured for 30 min in the presence of TNF or various concentrations of propofol, respectively, which were ...
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#2Pb Laursen (UQ: University of Queensland)H-Index: 5
Last. Jeff S. Coombes (UQ: University of Queensland)H-Index: 53
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Atherosclerotic plaque contains apoptotic endothelial cells with oxidative stress implicated in this process. Vitamin E and α-lipoic acid are a potent antioxidant combination with the potential to prevent endothelial apoptosis. Regular exercise is known to increase myocardial protection, however, little research has investigated the effects of exercise on the endothelium. The purpose of these studies was to investigate the effects of antioxidant supplementation and/or exercise training on protei...
41 CitationsSource
#1Stefan De HertH-Index: 13
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Background: Experimental studies have related the cardioprotective effects of sevoflurane both to preconditioning properties and to beneficial effects during reperfusion. In clinical studies, the cardioprotective effects of volatile agents seem more important when administered throughout the procedure than when used only in the preconditioning period. The authors hypothesized that the cardioprotective effects of sevoflurane observed in patients undergoing coronary surgery with cardiopulmonary by...
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Volatile anesthetics exert cardioprotective properties in experimental and clinical studies. We designed this study to investigate the effects of sevoflurane on left ventricular (LV) performance during minimally invasive direct coronary artery bypass grafting (MIDCAB) without cardiopulmonary bypass. Fifty-two patients scheduled for MIDCAB surgery were randomly assigned to a propofol or a sevoflurane group. Apart from the anesthetics used, there was no difference in surgical and anesthetic manage...
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Abstract Objective: To determine whether the antioxidant and anti-inflammatory properties of propofol confer benefit in adult patients undergoing elective coronary artery bypass grafting. Design: Prospective, blinded, randomized, controlled clinical investigation. Setting: Single-center, university teaching hospital and academic research laboratory. Participants: Twenty-one adult patients (11 control, 10 intervention) with chronic stable angina and normal ventricular function scheduled to underg...
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#1Kristin EngelhardH-Index: 25
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Previous studies have shown that reactive oxygen species mediated lipid peroxidation in patients undergoing cardiac surgery occurs primarily during cardiopulmonary bypass. We examined whether application of a high concen- tration of propofol during ischemia could effectively enhance postischemic myocardial functional recovery in the set- ting of global ischemia and reperfusion in an isolated heart preparation. Hearts were subjected to 40 min of global ischemia followed by 90 min of reperfusion. ...
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Summary Background and objective: Sevoflurane and propofol reduce the extent of necrosis and improve neurological outcome in rodent models of cerebral ischaemia and reperfusion. However, the effects of these anaesthetics on programmed cell death (apoptosis) are unclear. The present study investigates whether sevoflurane and propofol affect the expression of apoptosis-regulating proteins after cerebral ischaemia in rats. Methods: Thirty-two fasted male Sprague–Dawley rats were tracheally intubate...
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Background: Propofol reduces neuronal damage from cerebral ischemia when investigated for less than 8 postischemic days. This study investigates the long-term effects of propofol on neuronal damage and apoptosis-related proteins after cerebral ischemia and reperfusion. Methods: Male Sprague-Dawley rats were randomly assigned as follows: group 1 (n 32, control): fentanyl and nitrous oxide– oxygen; group 2 (n 32, propofol): propofol and oxygen–air. Ischemia (45 min) was induced by carotid artery o...
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