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A small dose of hydrogen peroxide enhances tumor necrosis factor-alpha toxicity in inducing human vascular endothelial cell apoptosis: Reversal with propofol

Published on Jul 1, 2006in Anesthesia & Analgesia3.49
· DOI :10.1213/01.ane.0000221183.02244.80
Tao Luo3
Estimated H-index: 3
,
Zhengyuan Xia32
Estimated H-index: 32
Cite
Abstract
We designed the present study to test the hypothesis that oxygen free radicals can enhance tumor necrosis factor (TNF)-α cellular toxicity, which might be reversed by propofol, an anesthetic with antioxidant properties, in human vascular endothelial cell line ECV304. Cultured ECV304 were either not
  • References (29)
  • Citations (56)
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References29
Newest
Published on Jun 1, 2005in Anesthesia & Analgesia3.49
Tao Luo3
Estimated H-index: 3
,
Zhengyuan Xia32
Estimated H-index: 32
+ 6 AuthorsXian-Yi Liu3
Estimated H-index: 3
We investigated whether propofol can inhibit tumor necrosis factor (TNF)-α-induced apoptosis in cultured human umbilical vein endothelial cells (HUVECs). Isolated HUVECs were cultured in Dulbecco's modified Eagle medium supplemented with 20% bovine calf serum. HUVECs in untreated and propofol control groups were cultured at 37°C for 24.5 h. HUVECs in the TNF treatment groups were initially cultured for 30 min in the presence of TNF or various concentrations of propofol, respectively, which were ...
Published on Mar 1, 2005in Anesthesia & Analgesia3.49
Berthold Bein42
Estimated H-index: 42
,
Jochen Renner25
Estimated H-index: 25
+ 5 AuthorsPeter H. Tonner29
Estimated H-index: 29
Volatile anesthetics exert cardioprotective properties in experimental and clinical studies. We designed this study to investigate the effects of sevoflurane on left ventricular (LV) performance during minimally invasive direct coronary artery bypass grafting (MIDCAB) without cardiopulmonary bypass. Fifty-two patients scheduled for MIDCAB surgery were randomly assigned to a propofol or a sevoflurane group. Apart from the anesthetics used, there was no difference in surgical and anesthetic manage...
Published on Mar 1, 2005in Journal of Molecular and Cellular Cardiology5.05
Susan A. Marsh18
Estimated H-index: 18
(UQ: University of Queensland),
Pb Laursen5
Estimated H-index: 5
(UQ: University of Queensland)
+ 2 AuthorsJeff S. Coombes52
Estimated H-index: 52
(UQ: University of Queensland)
Atherosclerotic plaque contains apoptotic endothelial cells with oxidative stress implicated in this process. Vitamin E and α-lipoic acid are a potent antioxidant combination with the potential to prevent endothelial apoptosis. Regular exercise is known to increase myocardial protection, however, little research has investigated the effects of exercise on the endothelium. The purpose of these studies was to investigate the effects of antioxidant supplementation and/or exercise training on protei...
Published on Mar 1, 2005in Anesthesiology6.42
Stefan G. De Hert28
Estimated H-index: 28
,
Philippe Van der Linden37
Estimated H-index: 37
+ 7 AuthorsInez I.E. Rodrigus6
Estimated H-index: 6
Background: Experimental studies have related the cardioprotective effects of sevoflurane both to preconditioning properties and to beneficial effects during reperfusion. In clinical studies, the cardioprotective effects of volatile agents seem more important when administered throughout the procedure than when used only in the preconditioning period. The authors hypothesized that the cardioprotective effects of sevoflurane observed in patients undergoing coronary surgery with cardiopulmonary by...
Published on Oct 1, 2004in Journal of Cardiothoracic and Vascular Anesthesia1.88
Tomas B. Corcoran1
Estimated H-index: 1
(UCC: University College Cork),
Arnth Engel1
Estimated H-index: 1
(UCC: University College Cork)
+ 4 AuthorsG. Shorten32
Estimated H-index: 32
(UCC: University College Cork)
Abstract Objective: To determine whether the antioxidant and anti-inflammatory properties of propofol confer benefit in adult patients undergoing elective coronary artery bypass grafting. Design: Prospective, blinded, randomized, controlled clinical investigation. Setting: Single-center, university teaching hospital and academic research laboratory. Participants: Twenty-one adult patients (11 control, 10 intervention) with chronic stable angina and normal ventricular function scheduled to underg...
Published on Oct 1, 2004in Canadian Journal of Physiology and Pharmacology2.04
Zhengyuan Xia32
Estimated H-index: 32
,
David V. Godin30
Estimated H-index: 30
,
David M. Ansley19
Estimated H-index: 19
Previous studies have shown that reactive oxygen species mediated lipid peroxidation in patients undergoing cardiac surgery occurs primarily during cardiopulmonary bypass. We examined whether application of a high concen- tration of propofol during ischemia could effectively enhance postischemic myocardial functional recovery in the set- ting of global ischemia and reperfusion in an isolated heart preparation. Hearts were subjected to 40 min of global ischemia followed by 90 min of reperfusion. ...
Published on Oct 1, 2004in Anesthesiology6.42
Kristin Engelhard24
Estimated H-index: 24
,
Christian Werner31
Estimated H-index: 31
+ 6 AuthorsEberhard Kochs41
Estimated H-index: 41
BACKGROUND: Propofol reduces neuronal damage from cerebral ischemia when investigated for less than 8 postischemic days. This study investigates the long-term effects of propofol on neuronal damage and apoptosis-related proteins after cerebral ischemia and reperfusion. METHODS: Male Sprague-Dawley rats were randomly assigned as follows: group 1 (n = 32, control): fentanyl and nitrous oxide-oxygen; group 2 (n = 32, propofol): propofol and oxygen-air. Ischemia (45 min) was induced by carotid arter...
Published on Jul 1, 2004in European Journal of Anaesthesiology4.14
K. Engelhard3
Estimated H-index: 3
(TUM: Technische Universität München),
C. Werner3
Estimated H-index: 3
(TUM: Technische Universität München)
+ 4 AuthorsEberhard Kochs41
Estimated H-index: 41
(TUM: Technische Universität München)
Background and objective: Sevoflurane and propofol reduce the extent of necrosis and improve neurological outcome in rodent models of cerebral ischaemia and reperfusion. However, the effects of these anaesthetics on programmed cell death (apoptosis) are unclear. The present study investigates whether sevoflurane and propofol affect the expression of apoptosis-regulating proteins after cerebral ischaemia in rats. Methods: Thirty-two fasted male Sprague-Dawley rats were tracheally intubated and th...
Published on Jan 1, 2004
Kristin Engelhard24
Estimated H-index: 24
,
Christian Werner31
Estimated H-index: 31
+ 6 AuthorsE. Kochs16
Estimated H-index: 16
Background: Propofol reduces neuronal damage from cerebral ischemia when investigated for less than 8 postischemic days. This study investigates the long-term effects of propofol on neuronal damage and apoptosis-related proteins after cerebral ischemia and reperfusion. Methods: Male Sprague-Dawley rats were randomly assigned as follows: group 1 (n 32, control): fentanyl and nitrous oxide– oxygen; group 2 (n 32, propofol): propofol and oxygen–air. Ischemia (45 min) was induced by carotid artery o...
Zhengyuan Xia32
Estimated H-index: 32
(WHU: Wuhan University),
Jiazhen Gu1
Estimated H-index: 1
(WHU: Wuhan University)
+ 2 AuthorsJinfu Yu1
Estimated H-index: 1
(WHU: Wuhan University)
Abstract Objective The endothelium-derived vasoconstrictor endothelin-1 is increased after cardiopulmonary bypass in children with congenital heart defects. This study determines whether antioxidant therapy with Salvia miltiorrhiza injection, an herb extract containing phenolic compounds, prevents the postoperative increase of endothelin-1. The relationship between endothelin-1 and the endothelium-derived prostacyclin (prostaglandin I2) and thromboxane A2 postoperatively is also investigated. Me...
Cited By56
Newest
Published on Dec 1, 2019in BMC Anesthesiology1.62
Yue Zhang (Fudan University), Xiaowei Ding2
Estimated H-index: 2
(Fudan University)
+ 1 AuthorsJiawei Chen10
Estimated H-index: 10
(Fudan University)
Background The levels of tight junction proteins (TJs), especially occludin, correlate with blood-brain barrier (BBB) disruption caused by inflammation in central nervous system (CNS). It has been reported that propofol, the most commonly used anesthetic, could inhibit inflammation response in CNS. In this study, we investigated the effects of tumor necrosis factor-α (TNF-α) and propofol on occludin expression in human cerebral microvascular endothelial cell line, D3 clone (hCMEC/D3 cells), and ...
Published on 2019in Journal of Food Biochemistry1.36
Yang Gao6
Estimated H-index: 6
(Changchun University),
Wei Zheng2
Estimated H-index: 2
(Changchun University)
+ 4 AuthorsDuoduo Xu5
Estimated H-index: 5
(Changchun University)
Published on Aug 1, 2019in Life Sciences3.45
Yilin Hong (JLU: Jilin University), Bo Nan1
Estimated H-index: 1
(JLU: Jilin University)
+ 2 AuthorsYuan Yuan3
Estimated H-index: 3
(JLU: Jilin University)
Abstract Aim Acrylamide (AA) is a common heat-generated toxicant in some food. Inhibiting its formation with natural antioxidants is of great significance. The current study aims to investigate the alleviative effect and the underlying mechanism of allicin against AA-induced oxidative stress in BRL-3A cells. Main methods BRL-3A cells were pretreated with allicin at different concentrations for 2 h, followed by AA treatment. Cell viability was determined by Cell Counting kit-8 (CCK-8). Intracellu...
Published on Oct 1, 2018in Biomedicine & Pharmacotherapy3.74
Khalil Ali Ahmad1
Estimated H-index: 1
(CPU: China Pharmaceutical University),
Hong Ze1
Estimated H-index: 1
(CPU: China Pharmaceutical University)
+ 4 AuthorsDing Qi-long2
Estimated H-index: 2
(CPU: China Pharmaceutical University)
Abstract Antioxidant therapy is considered as promising strategy for treating oxidative stress-induced cardiovascular disease. Bis (β-elemene-13-yl) glutarate (BEG) is a novel β-elemene derivative. Herein, we examined the antioxidant activity of BEG on human umbilical vein endothelial cells (HUVECs) after injury with hydrogen peroxide (H 2 O 2 ) and investigated the mechanism involved. HUVECs were divided into the following groups: control group (untreated cells); treated groups (cells treated w...
Published on Aug 1, 2018in European Journal of Pharmacology3.17
Liangqing Zhang6
Estimated H-index: 6
,
Zhihua Ruan1
Estimated H-index: 1
(HUM: Hubei University of Medicine)
+ 7 AuthorsZhe Hu5
Estimated H-index: 5
Abstract Ischemia-reperfusion injury(IRI), described as tissue damage caused by reversible ischemic injury or hypoxia prior to the blood supply restoration, is a common pathological phenomenon. In recent study, a hypoxia-reoxygenation (H/R) in the presence or absence of propofol posthypoxia treatment (P-PostH) cell model was built to simulate the condition of IRI, and researchers found propofol may protect cells by suppressing autophagic cell death. To investigate the mechanism underling the pro...
Published on Apr 1, 2018in Microcirculation2.68
Jiyuan Piao1
Estimated H-index: 1
(Kyung Hee University),
Hyun Sook Hong8
Estimated H-index: 8
(Kyung Hee University),
Youngsook Son19
Estimated H-index: 19
(Kyung Hee University)
Published on Sep 1, 2017in Experimental and Toxicologic Pathology
Savita Devi1
Estimated H-index: 1
(NDRI: National Dairy Research Institute),
Naveen Kumar7
Estimated H-index: 7
(NDRI: National Dairy Research Institute)
+ 4 AuthorsRajeev Kapila14
Estimated H-index: 14
(NDRI: National Dairy Research Institute)
Abstract Oxidative stress is one of a critical pathogenic factor in the progression of aging and chronic diseases such as cancer, myocardial inflammation and diabetes. In the present scenario, peptides with short half life and more biological specificities are gaining much attention as prodrugs. Thus, the present investigation carried out to screen potential antioxidative peptide, VLPVPQK to cope with the cellular oxidative damage. Our results showed that treatment of rat fibroblast cells with 0...
Published on Aug 1, 2017in Journal of Applied Ichthyology0.88
H.‐Y. Guo1
Estimated H-index: 1
(Ocean University of China),
X.‐Y. Dong1
Estimated H-index: 1
(Qingdao Agricultural University)
+ 2 AuthorsWentao Li17
Estimated H-index: 17
(Ocean University of China)
Published on Jul 3, 2017in International Journal of Food Properties1.40
Yan Qin3
Estimated H-index: 3
(NCU: Nanchang University),
Yong Sun3
Estimated H-index: 3
(NCU: Nanchang University)
+ 4 AuthorsLiHongyan13
Estimated H-index: 13
(NCU: Nanchang University)
ABSTRACTA highly sensitive high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry method was established for the identification of procyanidin components in the lotus seedpod, mangosteen pericarp, and camellia flower. It was shown that the main procyanidins of lotus seedpod were monomer, dimmer, and trimer-procyanidins, in which dimers and trimers were in the majority (80.8%). However, mangosteen pericarp and camellia flower procya...
View next paperRapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays