Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures
Abstract
Glioblastomas are grade IV brain tumors characterized by high aggressiveness and invasiveness, giving patients a poor prognosis. We investigated the effects of the multi-kinase inhibitor sorafenib on six cultures isolated from human glioblastomas and maintained in tumor initiating cells-enriching conditions. These cell subpopulations are thought to be responsible for tumor recurrence and radio- and chemo-resistance, representing the perfect...
Paper Details
Title
Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures
Published Date
Feb 1, 2013
Journal
Volume
12
Issue
3
Pages
491 - 500
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