Cholinergic dysfunction contributes to gait disturbance in early Parkinson's disease.
Abstract
Gait disturbance is an early feature in Parkinson’s disease. Its pathophysiology is poorly understood; however, cholinergic dysfunction may be a non-dopaminergic contributor to gait. Short-latency afferent inhibition is a surrogate measure of cholinergic activity, allowing the contribution of cholinergic dysfunction to gait to be evaluated. We hypothesized that short-latency afferent inhibition would be an independent predictor of gait...
Paper Details
Title
Cholinergic dysfunction contributes to gait disturbance in early Parkinson's disease.
Published Date
Sep 1, 2012
Journal
Volume
135
Issue
9
Pages
2779 - 2788
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Notes
History