GENETIC STUDIES IN FAMILIAL GOITROUS CRETINISM

The mode of inheritance of the gene producing goitrous cretinism in 3 sibs was studied by means of clinical and laboratory investigations of the available family members (3 generations). 8 relatives (including the mother of the patients) had more or less distinct cretinoid features, and 3 (also including the mother) had a small goitre. Isotope studies revealed various patterns of thyroid hypoactivity in 9 family members and a trend towards...