Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
Abstract
The cellular mechanisms underlying functional hyperemia--the coupling of neuronal activation to cerebral blood vessel responses--are not yet known. Here we show in rat cortical slices that the dilation of arterioles triggered by neuronal activity is dependent on glutamate-mediated [Ca(2+)](i) oscillations in astrocytes. Inhibition of these Ca(2+) responses resulted in the impairment of activity-dependent vasodilation, whereas selective...
Paper Details
Title
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
Published Date
Jan 1, 2003
Journal
Volume
6
Issue
1
Pages
43 - 50
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