Myeloperoxidase: A Leukocyte-Derived Protagonist of Inflammation and Cardiovascular Disease

Significance: The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil bactericidal proteins and is stored in large amounts inside azurophilic granules of neutrophils. Upon cell activation, MPO is released and extracellular MPO has been detected in a wide range of acute and chronic inflammatory conditions. Recent Advances and Critical Issues: Apart from its role during infection, MPO has emerged as a critical modulator of...