Developmental Dynamics and Disease Potential of Random Monoallelic Gene Expression

Volume: 28, Issue: 4, Pages: 366 - 380
Published: Feb 24, 2014
Abstract
X chromosome inactivation (XCI) and allelic exclusion of olfactory receptors or immunoglobulin loci represent classic examples of random monoallelic expression (RME). RME of some single copy genes has also been reported, but the in vivo relevance of this remains unclear. Here we identify several hundred RME genes in clonal neural progenitor cell lines derived from embryonic stem cells. RME occurs during differentiation, and, once established,...
Paper Details
Title
Developmental Dynamics and Disease Potential of Random Monoallelic Gene Expression
Published Date
Feb 24, 2014
Volume
28
Issue
4
Pages
366 - 380
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