Towards Selective Antagonists of T-Type Calcium Channels: Design, Characterization and Potential Applications of NNC 55-0396
Abstract
NNC 55-0396 is a structural analog of mibefradil (Ro 40-5967) that inhibits both T-type and high-voltage-activated (HVA) Ca2+ channels with a higher selectivity for T-type Ca2+ channels. The inhibitory effect of mibefradil on HVA Ca2+ channels can be attributed to a hydrolyzed metabolite of the drug: the methoxy acetate side chain of mibefradil is removed by intracellular enzymes, thus it forms (1...
Paper Details
Title
Towards Selective Antagonists of T-Type Calcium Channels: Design, Characterization and Potential Applications of NNC 55-0396
Published Date
Jun 7, 2006
Journal
Volume
23
Issue
2
Pages
173 - 196
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