Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites

We have recently shown that the amyloid βA4 precursor protein (APP) is synthesized in neurons and undergoes fast axonal transport to synaptic sites [Koo et al., Proc. Natl. Acad. Sci. U.S.A., 87 (1990) 1561–1565]. Using immunofluorescence, laser confocal microscopy and immunoelectron microscopy with simultaneous detection of APP and synaptophysin, we now report a preferential localization of APP at synaptic sits of human and rat brain and at...