Original paper

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

Science44.70
Volume: 343, Issue: 6166, Pages: 88 - 91
Published: Jan 3, 2014
Abstract
DNA Damage Repair In human cancers, oncogene activation interferes with DNA replication, leading to DNA replication stress and DNA double-strand breaks (DSBs). Costantino et al. (p. 88 , published online 5 December) identified two subunits of DNA polymerase delta, POL3 and POL4, as critical for survival of DNA replication stress in human cells. Both subunits were required for break-induced replication (BIR), which is required to repair a...
Paper Details
Title
Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells
Published Date
Jan 3, 2014
Journal
Volume
343
Issue
6166
Pages
88 - 91
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