Experimental conditions are important determinants of cardiac inotropic effects of propofol.
Abstract
Background null The rationale for this study is that the depressant effect of propofol on cardiac function in vitro is highly variable but may be explained by differences in the temperature and stimulation frequency used for the study. Both temperature and stimulation frequency are known to modulate cellular mechanisms that regulate intracellular free Ca2+ concentration ([Ca2+]i) and myofilament Ca2+ sensitivity in cardiac muscle. The authors...
Paper Details
Title
Experimental conditions are important determinants of cardiac inotropic effects of propofol.
Published Date
Nov 1, 2005
Journal
Volume
103
Issue
5
Pages
1026 - 1034
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Notes
History