Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Abstract
Calorie restriction (CR) extends lifespan in a wide spectrum of organisms and is the only regimen known to lengthen the lifespan of mammals1,2,3,4. We established a model of CR in budding yeast Saccharomyces cerevisiae. In this system, lifespan can be extended by limiting glucose or by reducing the activity of the glucose-sensing cyclic-AMP-dependent kinase (PKA)5. Lifespan extension in a mutant with reduced PKA activity requires Sir2 and NAD...
Paper Details
Title
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Published Date
Jul 1, 2002
Journal
Volume
418
Issue
6895
Pages
344 - 348
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