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Protective effect of propofol against kainic acid-induced lipid peroxidation in mouse brain homogenates: comparison with trolox and melatonin.

Published on Jul 1, 2005in Journal of Neurosurgical Anesthesiology2.96
· DOI :10.1097/01.ana.0000167143.67673.53
Hyung Lee28
Estimated H-index: 28
,
Young-Ho Jang6
Estimated H-index: 6
,
Seong-Ryong Lee23
Estimated H-index: 23
Cite
Abstract
Abstract:This study compared the effectiveness of propofol with that of trolox and melatonin for reduction of lipid peroxidation in vitro. Lipid peroxidation was induced by addition of kainic acid (KA; 10 mM), hydrogen peroxide (H2O2; 10 mM), or ferrous ammonium sulfate (5 μM) to mouse brain homogen
  • References (33)
  • Citations (15)
Cite
References33
Newest
Published on Sep 15, 2004in Journal of Neuroscience Research4.14
Hyung Lee28
Estimated H-index: 28
(KMU: Keimyung University),
Jae Hoon Bae1
Estimated H-index: 1
(KMU: Keimyung University),
Seong-Ryong Lee1
Estimated H-index: 1
(KMU: Keimyung University)
Previous studies have demonstrated that a green tea polyphenol, (−)-epigallocatechine gallate (EGCG), has a potent free radical scavenging and antioxidant effect. Glutamate leads to excitotoxicity and oxidative stress, which are important pathophysiologic responses to cerebral ischemia resulting in brain edema and neuronal damage. We investigated the effect of EGCG on excitotoxic neuronal damage in a culture system and the effect on brain edema formation and lesion after unilateral cerebral isch...
Published on Jul 1, 2001in Experimental Neurology4.56
Chengbiao Lu14
Estimated H-index: 14
(NIH: National Institutes of Health),
Mark P. Mattson177
Estimated H-index: 177
(NIH: National Institutes of Health)
Abstract Dimethyl sulfoxide (DMSO) is widely used in neuroscience research as a solvent for various pharmacological agents in both cell culture and in vivo studies and is also used in humans to treat musculoskeletal problems and pain. We now report that concentrations of DMSO to which neurons are typically exposed in experimental studies and in human patients (0.5–1.5%) inhibit glutamate responses in hippocampal neurons. DMSO suppresses, in a rapidly reversible manner, electrophysiological respo...
Published on Nov 1, 2000in Neuroscience Letters2.17
Joaquín García32
Estimated H-index: 32
(University of Texas Health Science Center at San Antonio),
Enrique Martínez-Ballarín14
Estimated H-index: 14
(University of Zaragoza)
+ 4 AuthorsDarío Acuña-Castroviejo54
Estimated H-index: 54
(UGR: University of Granada)
Abstract Tryptoline and pinoline are two β-carbolines isolated from the nervous system of mammals. We investigated the ability of these compounds to prevent lipid peroxidation induced by hydrogen peroxide in rat brain homogenates. We also compared their effects with other known antioxidants including melatonin, trolox and ascorbic acid. Lipid peroxidation was assessed by measuring malonaldehyde (MDA) and 4-hydroxy-alkenals (4-HDA) concentrations in the brain homogenates. Incubation with hydrogen...
Shigeki Yamaguchi12
Estimated H-index: 12
(Dokkyo University),
Shinsuke Hamaguchi8
Estimated H-index: 8
(Dokkyo University)
+ 2 AuthorsToshimitsu Kitajima17
Estimated H-index: 17
(Dokkyo University)
Purpose: To ascertain whether propofol prevents lipid peroxidation on delayed neuronal death induced by transient forebrain ischemia in the hippocampal CAI subfield in gerbils.
Published on Sep 1, 2000in European Journal of Pharmacology3.17
André Boland6
Estimated H-index: 6
(University of Liège),
Danielle Delapierre1
Estimated H-index: 1
(University of Liège)
+ 2 AuthorsAlbert Dresse20
Estimated H-index: 20
(University of Liège)
Abstract The anesthetic propofol (PPF) has been shown to be an antioxidant in acellular experiments. This study was designed to assess the ability of PPF to protect primary-cultured brain cells against iron-mediated toxicity. A comparison with trolox (TX), a hydrosoluble vitamin E analogue, was performed. Rat cortical cells were exposed to 10 μM FeSO 4 , PPF and/or TX. After a 4-h incubation, PPF and TX improved cell survival (lactate dehydrogenase measurements) in a concentration-dependent mann...
Published on Sep 1, 2000in Neuroscience Letters2.17
Felipe Dal-Pizzol39
Estimated H-index: 39
(UFRGS: Universidade Federal do Rio Grande do Sul),
Fábio Klamt26
Estimated H-index: 26
(UFRGS: Universidade Federal do Rio Grande do Sul)
+ 5 AuthorsRoger Walz38
Estimated H-index: 38
(UFRGS: Universidade Federal do Rio Grande do Sul)
Abstract Oxidative stress has been implicated in a variety of acute and chronic neurologic conditions, including epilepsy. Both the kainic acid and pilocarpine are useful models of temporal lobe epilepsy in rodents. As an index of lipid peroxidation the level thiobarbituric acid reactive substances (TBARS) was measured after the status epileticus induced by pilocarpine or kainic acid. In hippocampus there was a slight enhancement in the TBARS levels measured 12–14 h after the end of status epile...
Published on May 15, 2000in The Journal of Neuroscience6.07
Gordon W. Glazner18
Estimated H-index: 18
(UK: University of Kentucky),
Sic L. Chan47
Estimated H-index: 47
(UK: University of Kentucky)
+ 1 AuthorsMark P. Mattson177
Estimated H-index: 177
(UK: University of Kentucky)
Activation of ionotropic glutamate receptors of the AMPA and NMDA subtypes likely contributes to neuronal injury and death in various neurodegenerative disorders. Excitotoxicity can manifest as either apoptosis or necrosis, but the mechanisms that determine the mode of cell death are not known. We now report that levels of AMPA receptor subunits GluR-1 and GluR-4 are rapidly decreased in cultured rat hippocampal neurons undergoing apoptosis in response to withdrawal of trophic support (WTS), whe...
Published on Mar 1, 1999in Neurological Research1.98
S.-R. lee1
Estimated H-index: 1
(KMU: Keimyung University),
J.-K. Cheun1
Estimated H-index: 1
(KMU: Keimyung University)
AbstractThe goal of this study was to determine whether propofol has protective effect against kainic acid (KA)I. ndu~ed excftotoxicity. Administration of propofol (25 mg kg-7 i.p.) was done 2 h, before KA (10 mg kg-1 I.P.), Immedlatelyafte:1 and 2h, 4h, 6h, and 12 h afte~ the KAI and twice daily for an additional three days. Neuronal cell death In CA 1 an.d .CA3 subsector of hIppocampus was evaluated quantitatively four days after KA. The KA and propofol-Injected rats had a greater number of su...
Published on Jan 1, 1998in Journal of Pineal Research15.22
Janice Limson16
Estimated H-index: 16
,
Tebello Nyokong59
Estimated H-index: 59
,
Santy Daya23
Estimated H-index: 23
(Rhodes University)
Limson J, Nyokong T, Day a S. The interaction of melatonin and its precursors with aluminium, cadmium, copper, iron, lead, and zinc: An adsorptive voltammetric study. J. Pineal Res. 1998; 24:15–21. © Munksgaard, Copenhagen Abstract Melatonin, a pineal secretory product, and its precursors, tryptophan and serotonin, were examined for their metal binding affinities for both essential and toxic metals: aluminium, cadmium, copper, iron, lead, and zinc. An electrochemical technique, adsorptive stripp...
Published on Jan 1, 1997in Epilepsy Research2.18
Yuto Ueda20
Estimated H-index: 20
,
Hidekatsu Yokoyama19
Estimated H-index: 19
+ 3 AuthorsHitoshi Kamada26
Estimated H-index: 26
Abstract We report direct electron spin resonance (ESR) evidence of extracellular free radical formation during kainic acid-induced seizures obtained using in vivo brain microdialysis in freely moving rats. Saline solution containing the spin trap agent α -(4-pyridyl- N -oxide)- N -tert-butylnitrone was perfused through the hippocampus. ESR analysis of the dialysate samples revealed a six-line spectra, for which the hyperfine coupling constants corresponded to those of the ESR signal from the li...
Cited By15
Newest
Published on Feb 1, 2018in Neurochemical Research2.78
Wei Yu1
Estimated H-index: 1
(HMU: Harbin Medical University),
Dapeng Gao1
Estimated H-index: 1
(HMU: Harbin Medical University)
+ 2 AuthorsSihua Qi1
Estimated H-index: 1
(HMU: Harbin Medical University)
Oxidative stress caused by mitochondrial dysfunction during reperfusion is a key pathogenic mechanism in cerebral ischemia–reperfusion (IR) injury. Propofol (2,6-diisopropylphenol) has been proven to attenuate mitochondrial dysfunction and reperfusion injury. The current study reveals that propofol decreases oxidative stress injury by preventing succinate accumulation in focal cerebral IR injury. We evaluated whether propofol could attenuate ischemic accumulation of succinate in transient middle...
Published on Apr 1, 2017in Life Sciences3.45
Leticia Ester Delgado-Marín3
Estimated H-index: 3
(National University of Cordoba),
Mariela E. Sánchez-Borzone6
Estimated H-index: 6
(National University of Cordoba),
Daniel A. García18
Estimated H-index: 18
(National University of Cordoba)
Abstract Aims Various investigations have demonstrated the protective capacity of general anesthetics as neuroprotective agents. The effects of propofol against ischemia are known to reside in its antioxidant properties and its GABAergic activity. Other aromatic alcohols have also been reported as able to protect neurons against oxidative damage. The aim of this work is to evaluate the potential neuroprotective effect of some phenols, structurally analogues of propofol, with proven GABAergic act...
Published on Jan 1, 2015
W. Fan , X. Zhu + 4 AuthorsH. He
Propofol is a short-acting intra - venous anaesthetic agent and widely used not only in operating rooms but also in the intensive care unit (ICU). Apart from its multiple anaes - thetic advantages, the neuroprotective effect of propofol has been demonstrated in diverse mod - els of neuronal injury. The effect of propofol re - sults from activation of gamma-aminobutyric acid (GABA) receptor, modulation excitatory amino acid transmitter system and protecting brain cells against oxidative stress. M...
Published on Nov 21, 2014
Ischamie und Reperfusion (I/R) im Gastrointestinaltrakt konnen eine Dysfunktion der endothelialen und epithelialen Barriere verursachen und dadurch zur Translokation von Bakterien und schlieslich zum Multiorganversagen fuhren. In mehreren Studien wurde demonstriert, dass Anasthetika I/R-Schaden vermindern konnen, allerdings sind die zellularen und molekularen Mechanismen noch weitgehend ungeklart. Um die zellularen und molekularen Mechanismen der Wirkungen des intravenosen Anasthetikums Propofol...
Published on Sep 5, 2013in International Journal of Molecular Sciences4.18
Na Young Jung1
Estimated H-index: 1
,
Kyung Hee Lee6
Estimated H-index: 6
(Dongseo University)
+ 1 AuthorsBae Hwan Lee2
Estimated H-index: 2
(Severance Hospital)
Vitamin E, such as alpha-tocopherol (ATPH) and alpha-tocotrienol (ATTN), is a chain-breaking antioxidant that prevents the chain propagation step during lipid peroxidation. In the present study, we investigated the effects of ATTN on KA-induced neuronal death using organotypic hippocampal slice culture (OHSC) and compared the neuroprotective effects of ATTN and ATPH. After 15 h KA (5 μM) treatment, delayed neuronal death was detected in the CA3 region and reactive oxygen species (ROS) formation ...
Published on Jan 16, 2012in Journal of Medicinal Plants Research
Pérez-Juárez Angélica1
Estimated H-index: 1
,
Pacheco-Rosado Jorge1
Estimated H-index: 1
+ 2 AuthorsChamorro-Cevallos Germán1
Estimated H-index: 1
Oxidative stress has been implicated in the pathophysiology of neurologic disorders and brain dysfunctions. Spirulina (Arthrospira) maxima (SP) is a cyanobacteria with nutritional, pharmacological and important antioxidant activity. This study aims to evaluate the neuroprotective role of SP against kainic acid (KA) neurotoxicity. Male SW mice were treated with SP for 24 days (200, 400 and 800 mg/kg, (o.v.) and KA (35 mg/kg) was intraperitoneally administered as a single dose on day 14. After the...
Published on Apr 1, 2008in British Journal of Pharmacology6.58
H Shao1
Estimated H-index: 1
(Xuzhou Medical College),
J Li1
Estimated H-index: 1
(Xuzhou Medical College)
+ 4 AuthorsY Zeng1
Estimated H-index: 1
(Xuzhou Medical College)
Background and purpose: Ischaemia damages to the cardiac mitochondria by increasing generation of reactive oxygen species (ROS) and peroxidation of cardiolipin. The inhibited mitochondrial function leads to the cardiac injury during reperfusion. Propofol (2, 6-diisopropylphenol), an intravenous anaesthetic, has been shown to decrease cardiac ischaemia and reperfusion injury. In the present study, we propose that propofol protects mitochondrial function and decreases cardiac injury by prevention ...
Published on Feb 1, 2008in Experimental Biology and Medicine3.00
Xiao-Jing Zou3
Estimated H-index: 3
,
Le Yang3
Estimated H-index: 3
,
Shanglong Yao4
Estimated H-index: 4
Cardiomyocyte hypertrophy is formed in response to pressure or volume overload, injury, or neurohormonal activation. The most important vascular hormone that contributes to the development of hypertrophy is angiotensin II (Ang II). Accumulating studies have suggested that reactive oxygen species (ROS) may play an important role in cardiac hypertrophy. Propofol is a general anesthetic that possesses antioxidant action. We therefore examined whether propofol inhibited Ang II–induced cardiomyocyte ...
View next paperKainate-induced lipid peroxidation in rat brain in vitro is markedly reduced by the endogenous antioxidant melatonin