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Protective effect of propofol against kainic acid-induced lipid peroxidation in mouse brain homogenates: comparison with trolox and melatonin.

Published on Jul 1, 2005in Journal of Neurosurgical Anesthesiology2.957
· DOI :10.1097/01.ana.0000167143.67673.53
Hyung Keun Lee25
Estimated H-index: 25
,
Young-Ho Jang6
Estimated H-index: 6
,
Seong-Ryong Lee23
Estimated H-index: 23
Abstract
Abstract:This study compared the effectiveness of propofol with that of trolox and melatonin for reduction of lipid peroxidation in vitro. Lipid peroxidation was induced by addition of kainic acid (KA; 10 mM), hydrogen peroxide (H2O2; 10 mM), or ferrous ammonium sulfate (5 μM) to mouse brain homogen
  • References (33)
  • Citations (15)
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References33
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Previous studies have demonstrated that a green tea polyphenol, (−)-epigallocatechine gallate (EGCG), has a potent free radical scavenging and antioxidant effect. Glutamate leads to excitotoxicity and oxidative stress, which are important pathophysiologic responses to cerebral ischemia resulting in brain edema and neuronal damage. We investigated the effect of EGCG on excitotoxic neuronal damage in a culture system and the effect on brain edema formation and lesion after unilateral cerebral isch...
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Abstract Tryptoline and pinoline are two β-carbolines isolated from the nervous system of mammals. We investigated the ability of these compounds to prevent lipid peroxidation induced by hydrogen peroxide in rat brain homogenates. We also compared their effects with other known antioxidants including melatonin, trolox and ascorbic acid. Lipid peroxidation was assessed by measuring malonaldehyde (MDA) and 4-hydroxy-alkenals (4-HDA) concentrations in the brain homogenates. Incubation with hydrogen...
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The anesthetic propofol (PPF) has been shown to be an antioxidant in acellular experiments. This study was designed to assess the ability of PPF to protect primary-cultured brain cells against iron-mediated toxicity. A comparison with trolox (TX), a hydrosoluble vitamin E analogue, was performed. Rat cortical cells were exposed to 10 μM FeSO4, PPF and/or TX. After a 4-h incubation, PPF and TX improved cell survival (lactate dehydrogenase measurements) in a concentration-dependent manner. The res...
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Abstract Oxidative stress has been implicated in a variety of acute and chronic neurologic conditions, including epilepsy. Both the kainic acid and pilocarpine are useful models of temporal lobe epilepsy in rodents. As an index of lipid peroxidation the level thiobarbituric acid reactive substances (TBARS) was measured after the status epileticus induced by pilocarpine or kainic acid. In hippocampus there was a slight enhancement in the TBARS levels measured 12–14 h after the end of status epile...
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AbstractThe goal of this study was to determine whether propofol has protective effect against kainic acid (KA)I. ndu~ed excftotoxicity. Administration of propofol (25 mg kg-7 i.p.) was done 2 h, before KA (10 mg kg-1 I.P.), Immedlatelyafte:1 and 2h, 4h, 6h, and 12 h afte~ the KAI and twice daily for an additional three days. Neuronal cell death In CA 1 an.d .CA3 subsector of hIppocampus was evaluated quantitatively four days after KA. The KA and propofol-Injected rats had a greater number of su...
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Limson J, Nyokong T, Day a S. The interaction of melatonin and its precursors with aluminium, cadmium, copper, iron, lead, and zinc: An adsorptive voltammetric study. J. Pineal Res. 1998; 24:15–21. © Munksgaard, Copenhagen Abstract Melatonin, a pineal secretory product, and its precursors, tryptophan and serotonin, were examined for their metal binding affinities for both essential and toxic metals: aluminium, cadmium, copper, iron, lead, and zinc. An electrochemical technique, adsorptive stripp...
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Ischamie und Reperfusion (I/R) im Gastrointestinaltrakt konnen eine Dysfunktion der endothelialen und epithelialen Barriere verursachen und dadurch zur Translokation von Bakterien und schlieslich zum Multiorganversagen fuhren. In mehreren Studien wurde demonstriert, dass Anasthetika I/R-Schaden vermindern konnen, allerdings sind die zellularen und molekularen Mechanismen noch weitgehend ungeklart. Um die zellularen und molekularen Mechanismen der Wirkungen des intravenosen Anasthetikums Propofol...
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Background and purpose: Ischaemia damages to the cardiac mitochondria by increasing generation of reactive oxygen species (ROS) and peroxidation of cardiolipin. The inhibited mitochondrial function leads to the cardiac injury during reperfusion. Propofol (2, 6-diisopropylphenol), an intravenous anaesthetic, has been shown to decrease cardiac ischaemia and reperfusion injury. In the present study, we propose that propofol protects mitochondrial function and decreases cardiac injury by prevention ...
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