Secondary mutations as a mechanism of cisplatin resistance in BRCA2 -mutated cancers

Nature64.80
Volume: 451, Issue: 7182, Pages: 1116 - 1120
Published: Feb 28, 2008
Abstract
Ovarian carcinomas with mutations in the tumour suppressor BRCA2 are particularly sensitive to platinum compounds. However, such carcinomas ultimately develop cisplatin resistance. The mechanism of that resistance is largely unknown. Here we show that acquired resistance to cisplatin can be mediated by secondary intragenic mutations in BRCA2 that restore the wild-type BRCA2 reading frame. First, in a cisplatin-resistant BRCA2-mutated...
Paper Details
Title
Secondary mutations as a mechanism of cisplatin resistance in BRCA2 -mutated cancers
Published Date
Feb 28, 2008
Journal
Volume
451
Issue
7182
Pages
1116 - 1120
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