mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Abstract
Epigenetic reprogramming of myeloid cells, also known as trained immunity, confers nonspecific protection from secondary infections. Using histone modification profiles of human monocytes trained with the Candida albicans cell wall constituent β-glucan, together with a genome-wide transcriptome, we identified the induced expression of genes involved in glucose metabolism. Trained monocytes display high glucose consumption, high lactate...
Paper Details
Title
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Published Date
Sep 26, 2014
Journal
Volume
345
Issue
6204
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Notes
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