Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
Abstract
Autism spectrum disorders comprise a range of neurodevelopmental disorders characterized by deficits in social interaction and communication, and by repetitive behaviour. Mutations in synaptic proteins such as neuroligins, neurexins, GKAPs/SAPAPs and ProSAPs/Shanks were identified in patients with autism spectrum disorder, but the causative mechanisms remain largely unknown. ProSAPs/Shanks build large homo- and heteromeric protein complexes at...
Paper Details
Title
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
Published Date
Jun 14, 2012
Journal
Volume
486
Issue
7402
Pages
256 - 260
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