Hypoxia, HIF1 and glucose metabolism in the solid tumour
Abstract
It has been known for many years that cellular metabolism within the solid tumour is markedly different from that of the corresponding normal tissue. The transcription factor hypoxia-inducible factor 1 (HIF1) has been implicated in regulating many of the genes that are responsible for the metabolic difference. However, it remains unclear how this 'aerobic glycolysis', originally described by Otto Warburg, offers tumour cells a growth advantage....
Paper Details
Title
Hypoxia, HIF1 and glucose metabolism in the solid tumour
Published Date
Aug 14, 2008
Journal
Volume
8
Issue
9
Pages
705 - 713
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Notes
History