Trace fluorescent labeling for high-throughput crystallography.

Volume: 62, Issue: 3, Pages: 339 - 346
Published: Mar 1, 2006
Abstract
Covalent labeling of macromolecules with trace levels (<1%) of a fluorescent dye is proposed as a means to facilitate finding or detecting crystals in crystallization drops. To test the effects of labeled protein concentration on the resulting X-ray diffraction data, experiments were carried out with the model proteins insulin, ribonuclease, lysozyme and thaumatin, which were labeled with the fluorescent dye carboxyrhodamine. All proteins were...
Paper Details
Title
Trace fluorescent labeling for high-throughput crystallography.
Published Date
Mar 1, 2006
Volume
62
Issue
3
Pages
339 - 346
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