In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery
Abstract
A variety of approaches have been studied in the past to overcome the problems encountered with the oral delivery of insulin, but with little success. In this study, self-assembled nanoparticles (NPs) with a pH-sensitive characteristic were prepared by mixing the anionic poly-gamma-glutamic acid solution with the cationic chitosan solution in the presence of MgSO(4) and sodium tripolyphosphate. The in vitro results found that the transport of...
Paper Details
Title
In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery
Published Date
Apr 1, 2009
Journal
Volume
30
Issue
12
Pages
2329 - 2339
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