Fatty Acids and Insulin Resistance
Abstract
We have demonstrated that physiological elevations in plasma free fatty acid concentrations inhibit insulin-stimulated glucose uptake in a dose-dependent manner in normal control subjects and in patients with NIDDM. Two possible mechanisms were identified: 1) a fat-related inhibition of glucose transport or phosphorylation that appeared after 3-4 h of fat infusion and 2) a decrease in muscle glycogen synthase activity that appeared after 4-6 h...
Paper Details
Title
Fatty Acids and Insulin Resistance
Published Date
Apr 1, 1996
Journal
Volume
19
Issue
4
Pages
394 - 395
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Notes
History