Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

Cell64.50
Volume: 76, Issue: 6, Pages: 969 - 976
Published: Mar 25, 1994
Abstract
null Mice homozygous for null lpr null (lymphoproliferation) or null gld null (generalized lymphoproliferative disease) develop lymphadenopathy and suffer from autoimmune disease. The null lpr null mice have a mutation in a cell-surface protein, Fas, that mediates apoptosis. Fas ligand (FasL) is a tumor necrosis factor (TNF)-related type II membrane protein and binds to Fas. Here, mouse null Fasl null gene was isolated and localized to the null...
Paper Details
Title
Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand
Published Date
Mar 25, 1994
Journal
Volume
76
Issue
6
Pages
969 - 976
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