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Physical Activity, Growth, and Inflammatory Mediators in BMI-Matched Female Adolescents

Published on Jul 1, 2007in Medicine and Science in Sports and Exercise4.48
· DOI :10.1249/mss.0b013e318053e7a2
Mariam Ischander1
Estimated H-index: 1
,
Frank Zaldivar29
Estimated H-index: 29
+ 5 AuthorsMargaret Schneider22
Estimated H-index: 22
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Abstract
Purpose: Physical inactivity is deleterious to health, but it has been difficult to determine the extent to which these effects are attributable to abnormal body composition or to factors related to physical activity alone. To begin to gauge independent effects of physical activity on health risk, we matched by BMI two groups of normal-weight adolescent females, one physically active (all participants in high school sports), and one sedentary. Methods: Thirty-seven sedentary and 37 physically active adolescent females (mean 15.5 yr) were matched for age and BMI percentile (mean = 58.8). Comparisons included fitness, body composition and bone mineralization (by DEXA), circulating inflammatory cytokines, growth factors, bone-turnover markers, leptin, and adiponectin. Results: Compared with the normal-weight sedentary girls, active girls had significantly (P < 0.05) higher fitness level (peak V?O2 35.5 ± 5.2 vs 24.4 ± 4.1 mL·kg-1·min-1), lean body mass (43.2 ± 4.4 vs 38.7 ± 3.6 kg), bone mineralization (spinal BMD z-scores 0.04 ± 0.88 vs -0.41 ± 0.85), and lower percent body fat (25.4 ± 04.6 vs 29.7 ± 03.7%). Additionally, active girls had lower inflammatory cytokines levels (e.g., TNF-a 1.7 ± 1.3 vs 2.6 ± 2.2 pg·mL-1), and leptin (17.4 ± 11.2 vs 24.7 ± 14.7 ng·mL-1), and higher bone-turnover markers (e.g. osteocalcin 12.6 ± 7.6 vs 7.8 ± 3.0 U·L-1), IGFBP-3 (6416 ± 21280 vs 4247 ± 1082 ng·mL-1), and adiponectin levels (11919 ± 3935 vs 9305 ± 2843 ng·mL-1). Conclusion: The normal-weight, physically active group was fitter and had greater lean body mass, stronger bones, and lower levels of inflammatory markers than did the normal-weight, sedentary group. In adolescent girls, the choice of a lifestyle involving high school sports is characterized by a circulating mediator and body composition pattern that, if sustained, is associated with generally lower long-term risk of cardiovascular disease and osteoporosis
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  • References (23)
  • Citations (54)
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References23
Newest
Published on Jun 1, 2006in International Journal of Cardiology3.47
Jamal S. Rana4
Estimated H-index: 4
(University of Pittsburgh),
Khurram Nasir34
Estimated H-index: 34
(University of Pittsburgh)
+ 5 AuthorsRoger S. Blumenthal35
Estimated H-index: 35
(JHUSOM: Johns Hopkins University School of Medicine)
Abstract Objective The presence of metabolic syndrome is associated with a higher degree of inflammation. We sought to assess whether the higher levels of cardiorespiratory fitness attenuate the levels of inflammation in people with metabolic syndrome. Research design and methods We studied 449 consecutive asymptomatic men (47±7 years) who underwent a maximal treadmill exercise test according to the Bruce protocol. Cardiorespiratory fitness was divided into tertiles based on metabolic equivalent...
Published on Jun 1, 2006in International Journal of Obesity4.51
Frank Zaldivar29
Estimated H-index: 29
(UCI: University of California, Irvine),
Robert G. McMurray45
Estimated H-index: 45
(UNC: University of North Carolina at Chapel Hill)
+ 3 AuthorsDan M. Cooper48
Estimated H-index: 48
(UCI: University of California, Irvine)
Top of pageAbstract Objective: To determine the effects of obesity on baseline levels of circulating granulocytes, monocytes, and lymphocyte subtypes in otherwise healthy children. Design: Two group comparison of leukocytes in normal weight control and overweight children. Subjects: In total, 38 boys and girls, ages 6–18 years, divided in two groups: normal weight, (NW, BMI 85th %tile, n=23). Measurements: BMI obtained from direct measures of height and body mass. Body fat was assessed by DEXA. ...
Published on May 1, 2006in Pediatric Exercise Science1.71
Genevieve F. Dunton29
Estimated H-index: 29
,
Margaret Schneider22
Estimated H-index: 22
+ 1 AuthorsDan M. Cooper48
Estimated H-index: 48
Cross-sectional research examined whether physical activity or physical fitness was more closely linked to physical self-concept in adolescent females ages 14 to 17 (N = 103, 63% Caucasian). Moderate physical activity and vigorous physical activity were measured through a 3-day physical activity recall. Physical fitness was assessed using highly accurate measures of peak oxygen consumption (via cycle ergometer) and percent body fat (via dual X-ray absorptiometer). The Physical Self-Description Q...
Published on Mar 1, 2006in Osteoporosis International3.82
Curtis Cooper163
Estimated H-index: 163
(Southampton General Hospital),
Sarah Westlake4
Estimated H-index: 4
(Southampton General Hospital)
+ 3 AuthorsMark A. Hanson80
Estimated H-index: 80
(Southampton General Hospital)
Osteoporosis is a major cause of morbidity and mortality through its association with age-related fractures. Although most effort in fracture prevention has been directed at retarding the rate of age-related bone loss and reducing the frequency and severity of trauma among elderly people, evidence is growing that peak bone mass is an important contributor to bone strength during later life. The normal patterns of skeletal growth have been well characterised in cross-sectional and longitudinal st...
Published on Dec 21, 2005in JAMA51.27
Mercedes R. Carnethon52
Estimated H-index: 52
,
Martha Gulati24
Estimated H-index: 24
(NU: Northwestern University),
Philip Greenland92
Estimated H-index: 92
ContextPopulation surveys indicate that physical activity levels are low in the United States. One consequence of inactivity, low cardiorespiratory fitness, is an established risk factor for cardiovascular disease (CVD) morbidity and mortality, but the prevalence of cardiorespiratory fitness has not been quantified in representative US population samples.ObjectivesTo describe the prevalence of low fitness in the US population aged 12 through 49 years and to relate low fitness to CVD risk factors...
Published on Dec 1, 2005in The American Journal of the Medical Sciences1.96
Louise J. Hutley15
Estimated H-index: 15
(UQ: University of Queensland),
John Prins59
Estimated H-index: 59
(UQ: University of Queensland)
Obesity and the metabolic syndrome have both reached pandemic proportions. Together they have the potential to impact on the incidence and severity of cardiovascular pathologies, with grave implications for worldwide health care systems. The metabolic syndrome is characterized by visceral obesity, insulin resistance, hypertension, chronic inflammation, and thrombotic disorders contributing to endothelial dysfunction and, subsequently, to accelerated atherosclerosis. Obesity is a key component in...
Published on Nov 1, 2005in Metabolism-clinical and Experimental6.51
George P. Nassis21
Estimated H-index: 21
(HUA: Harokopio University),
Katerina Papantakou1
Estimated H-index: 1
(HUA: Harokopio University)
+ 5 AuthorsL. S. Sidossis41
Estimated H-index: 41
(HUA: Harokopio University)
Abstract The aim of this study was to examine the effect of aerobic exercise training on insulin sensitivity in overweight and obese girls. Nineteen overweight and obese girls (mean ± SD: age, 13.1 ± 1.8 years; body mass index, 26.8 ± 3.9 kg/m 2 ) volunteered for this study. Body composition (dual-energy x-ray absorptiometry), insulin sensitivity (oral glucose tolerance test and homeostasis model assessment estimate of insulin resistance; n=15), adiponectin, C-reactive protein (CRP), interleukin...
Published on Jun 1, 2005in The Journal of Clinical Endocrinology and Metabolism5.61
Ram Weiss33
Estimated H-index: 33
,
Sara E. Taksali19
Estimated H-index: 19
+ 7 AuthorsSonia Caprio65
Estimated H-index: 65
There is a wide interindividual variation in peripheral insulin sensitivity at any given body mass index or percent body fat among obese adolescents with normal glucose tolerance. The goals of this study were to determine whether variability in insulin sensitivity is associated with differences in patterns of lipid partitioning or substrate use under fasting and hyperinsulinemic conditions. We compared 14 obese insulin-resistant adolescents with 14 obese insulin-sensitive controls, pair matched ...
Published on May 1, 2005in Journal of the American College of Cardiology18.64
Christos Kasapis1
Estimated H-index: 1
(UConn: University of Connecticut),
Paul D. Thompson83
Estimated H-index: 83
(Hartford Hospital)
Physical activity is associated with a reduced incidence of coronary disease, but the mechanisms mediating this effect are not defined. There has been considerable recent interest in inflammation in the pathogenesis of cardiovascular disease. Some of the beneficial role of physical activity may result from its effects on the inflammatory process. We searched PubMed for articles published between 1975 through May 2004 using the terms exercise, physical activity, or physical fitness combined with ...
Published on Oct 1, 2004in Atherosclerosis4.25
D. Verdaet1
Estimated H-index: 1
(Free University of Brussels),
Paul Dendale30
Estimated H-index: 30
+ 3 AuthorsGui De Backer79
Estimated H-index: 79
(UGent: Ghent University)
Abstract Background: Some markers of chronic inflammation have been recognized as predictors of cardiovascular risk in apparently healthy subjects and in patients with coronary heart disease (CHD). High sensitivity C-reactive protein (CRP) appears to be the most useful marker in clinical settings. Several studies reported associations between inflammatory markers and other cardiovascular risk factors, such as age, obesity, cholesterol levels, the presence of diabetes mellitus, physical activity,...
Cited By54
Newest
Published on Jul 4, 2018in European Journal of Nutrition4.45
Aline Arouca2
Estimated H-index: 2
(UGent: Ghent University),
Alba M. Santaliestra-Pasías12
Estimated H-index: 12
(University of Zaragoza)
+ 15 AuthorsMathilde Kersting43
Estimated H-index: 43
(RUB: Ruhr University Bochum)
AIM: To assess if a healthy diet might attenuate the positive sedentary-inflammation relation, whereas an unhealthy diet may increase the effect of sedentary behaviors on inflammatory biomarkers.ME ...
Published on Jan 2, 2019in Journal of Sports Sciences2.81
Luiz Rodrigo Augustemak de Lima6
Estimated H-index: 6
(UFSC: Universidade Federal de Santa Catarina),
Isabela de Carlos Back2
Estimated H-index: 2
(UFSC: Universidade Federal de Santa Catarina)
+ 2 AuthorsEdio Luiz Petroski22
Estimated H-index: 22
(UFSC: Universidade Federal de Santa Catarina)
ABSTRACTThis study aimed to investigate if moderate to vigorous physical activity (MVPA) and aerobic fitness are associated with cardiovascular risk factors in HIV+ children and adolescents. Sixty-five children and adolescents (8 to 15 years) provided minutes of MVPA measured by accelerometers and peak oxygen uptake (peak VO2) by breath-by-breath respiratory exchange. Cardiovascular risk factors were characterized by body fat, blood pressure, total cholesterol, HDL-c, LDL-c, triglycerides, gluco...
Published on Dec 1, 2018in BMC Pediatrics1.98
Marco Antonio Cossio-Bolaños5
Estimated H-index: 5
(State University of Campinas),
Cynthia Lee-Andruske + 3 AuthorsRossana Gómez-Campos4
Estimated H-index: 4
(State University of Campinas)
Maintaining and building healthy bones during the lifetime requires a complicated interaction between a number of physiological and lifestyle factors. Our goal of this study was to analyze the association between hand grip strength and the maximum peak expiratory flow with bone mineral density and content in adolescent students. The research team studied 1427 adolescent students of both sexes (750 males and 677 females) between the ages of 11.0 and 18.9 years in the Maule Region of Talca (Chile)...
Published on Aug 9, 2017in European Journal of Sport Science2.38
Jaak Jürimäe24
Estimated H-index: 24
(UT: University of Tartu),
Kristel Võsoberg2
Estimated H-index: 2
(UT: University of Tartu)
+ 3 AuthorsVallo Tillmann25
Estimated H-index: 25
(UT: University of Tartu)
AbstractVarious inflammation parameters are increased with childhood obesity, but few comparable data are found in lean growing athletes. This study aims to characterize differences in 12 simultaneously measured inflammatory parameters between pubertal rhythmic gymnasts (RG) and untrained controls (UC), and to examine the relationship between body composition and inflammatory markers. Sixty 10–12-year-old girls were divided into RG (n = 30) and UC (n = 30). Fat mass (FM) and fat free mass (FFM) ...
Published on Oct 1, 2016in Animal2.03
M. M. J. van Riet4
Estimated H-index: 4
,
Sam Millet16
Estimated H-index: 16
+ 5 AuthorsGeert Janssens27
Estimated H-index: 27
Bone metabolism fluctuates throughout the reproductive cycle of sows to enable foetal growth and milk production. Although increased bone mineralisation is conceivable in sows during reproduction, a study of mineralisation in function of parity has not been performed. This study evaluated the fluctuations of markers for bone metabolism in primiparous and multiparous sows throughout a reproductive cycle. The experiment included ten multiparous and five primiparous commercial hybrid sows from one ...
Published on Jun 1, 2016in Revista Brasileira De Medicina Do Esporte0.24
Valter Paulo Neves Miranda1
Estimated H-index: 1
(UFV: Universidade Federal de Viçosa),
Paulo Roberto dos Santos Amorim9
Estimated H-index: 9
(UFV: Universidade Federal de Viçosa)
+ 2 AuthorsSilvia Eloiza Priore21
Estimated H-index: 21
(UFV: Universidade Federal de Viçosa)
La acumulacion de grasa corporal es uno de los principales factores de riesgo de enfermedades cardiometabolicas. La obesidad puede ser considerada como una enfermedad inflamatoria sistemica cronica en adultos y en los jovenes. El control del proceso de inflamacion subclinica a traves de la practica de actividad fisica (AF) puede mitigar los efectos de los factores de riesgo que desencadenan la aterosclerosis, que empeora con la edad. El objetivo de este estudio fue realizar una revision sistemat...
Published on Jan 1, 2016
abstract The accumulation of body fat is a major risk factor for cardiometabolic diseases. Obesity can be considered a chronic systemic inflammatory disease in adults and younger people. The control of subclinical inflamma-tion process through the practice of physical activity (PA) can mitigate the effects of risk factors that trigger atherosclerosis that worsens with advancing age. The objective of this study was to conduct a systematic review of the influence of physical activity and/or exerci...
Published on Jan 1, 2016
Filip Neuls3
Estimated H-index: 3
,
Karel Frömel12
Estimated H-index: 12
Published on Sep 1, 2015in Cadernos De Saude Publica1.17
Cesar Aparecido Agostinis Sobrinho2
Estimated H-index: 2
(University of Porto),
Carla Marisa Maia Moreira2
Estimated H-index: 2
(University of Porto)
+ 1 AuthorsRute Santos25
Estimated H-index: 25
The goal of this study was to investigate the association of physical activity (PA) and cardiorespiratory fitness with C-reactive protein (CRP) concentration in adolescents. The sample included 386 Portuguese adolescents (n = 207, female), age 12-18 years, assessed in the year 2012. The PA was assessed with the use of accelerometers, and the cardiorespiratory fitness was assessed by the Fitnessgram Pacer test. Blood samples were collected after a 10-hour fasting, and high-sensitivity PCR concent...