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Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid
Published on Mar 1, 1998in The Journal of Clinical Endocrinology and Metabolism 5.79
· DOI :10.1210/jcem.83.3.4660
Susan K. Fried47
Estimated H-index: 47
,
Dove A. Bunkin1
Estimated H-index: 1
,
Andrew S. Greenberg66
Estimated H-index: 66
Abstract
The purpose of this study was to determine whether human adipocytes from different depots of obese subjects produce interleukin-6 (IL-6) and whether IL-6 release is regulated by glucocorticoids. Fragments of omental and abdominal sc adipose tissue released immunodetectable IL-6 into the medium during acute incubations. Omental adipose tissue released 2–3 times more IL-6 than did sc adipose tissue. Isolated adipocytes prepared from these tissues also released IL-6 (omental> sc), but this accounted for only 10% of the total tissue release. Culture of adipose tissue fragments for 7 days with the glucocorticoid dexamethasone markedly suppressed IL-6 production. These data show for the first time that substantial quantities of IL-6 (up to 75 ng/mL) accumulate in the medium during incubations of both adipocytes and adipose tissue. Although little is known about the effects of IL-6 on adipose tissue, one action is a down-regulation of adipose tissue lipoprotein lipase. The regulated production of this multifunct...
  • References (34)
  • Cited By (1346)
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References34
Published on Dec 5, 1985in Journal of Biological Chemistry 4.01
R C Honnor3
Estimated H-index: 3
,
G S Dhillon3
Estimated H-index: 3
,
C Londos3
Estimated H-index: 3
Abstract With the use of -cAMP/+cAMP activity ratios of cAMP-dependent protein kinase (A-kinase) in fat cell extracts as an index of cellular cAMP concentrations, it is apparent from both the current literature and from data presented in this paper that classical cell isolation procedures yield cells whose behavior is unpredictable from day to day. Herein, procedures are described for isolating adipocytes, preparing cytosolic extracts, and assaying A-kinase that result in kinase activity ratios ...
214 Citations
Published on Aug 1, 1992in Cancer Research 9.13
Andrew S. Greenberg66
Estimated H-index: 66
,
Richard P. Nordan2
Estimated H-index: 2
+ 3 AuthorsDavid M. Jablons52
Estimated H-index: 52
To investigate whether interleukin 6 (IL-6) might be a potential mediator of the depleted fat reserves observed in malignancy-associated cachexia, we measured lipoprotein lipase (LPL) activity in adipose tissue of mice after administration of IL-6 or tumor necrosis factor and in cultured adipocytes after addition of these cytokines. Injection of IL-6 i.p. reduced adipose tissue LPL activity by 53% within 4.5 to 5.5 h. Injection of tumor necrosis factor elevated serum IL-6 levels and reduced adip...
246 Citations
Published on Jan 1, 1997in Molecular Medicine 3.34
Fahumiya Samad14
Estimated H-index: 14
(Scripps Research Institute),
Koji Yamamoto4
Estimated H-index: 4
(Scripps Research Institute)
+ 1 AuthorsDavid J. Loskutoff72
Estimated H-index: 72
(Scripps Research Institute)
Tumor necrosis factor-α (TNF-α) is chronically elevated in the adipose tissue from obese humans and mice. This increase in TNF-α contributes to the insulin resistance, elevated plasminogen activator inhibitor-1 (PAI-1) levels, and cardiovascular complications associated with obesity and noninsulin-dependent diabetes (NIDDM). PAI-1 gene expression in adipose tissue is also stimulated by transforming growth factor-β (TGF-β). Experiments were performed to determine whether TGF-β is regulated by TNF...
214 Citations Source Cite
Published on Apr 5, 1993in Journal of Biological Chemistry 4.01
Bruce M. Spiegelman161
Estimated H-index: 161
,
Lisa Choy7
Estimated H-index: 7
+ 2 AuthorsPeter Tontonoz75
Estimated H-index: 75
242 Citations
Dimitris A. Papanicolaou31
Estimated H-index: 31
(National Institutes of Health),
J. S. Petrides2
Estimated H-index: 2
(National Institutes of Health)
+ 6 AuthorsGeorge P. Chrousos147
Estimated H-index: 147
(National Institutes of Health)
In experimental animals, stress and catecholamines stimulate endogenous interleukin-6 (IL-6) secretion, whereas glucocorticoids inhibit it. To examine whether physical stress alters the secretion of IL-6 in humans, and to what extent this is correlated with catecholamines and modified by glucocorticoids, we performed high-intensity treadmill exercise test runs on 15 male volunteers, in a double-blind crossover design, after pretreatment with placebo, hydrocortisone, or dexamethasone. Plasma epin...
178 Citations Source Cite
Published on Apr 1, 1996in Molecular and Cellular Endocrinology 3.56
Miranda B Crichton1
Estimated H-index: 1
(University of Texas Southwestern Medical Center),
John E. Nichols5
Estimated H-index: 5
(University of Texas Southwestern Medical Center)
+ 2 AuthorsEvan R. Simpson59
Estimated H-index: 59
(University of Texas Southwestern Medical Center)
Abstract The expression of transcripts of cytokines of the interleukin-6 (IL-6) family has been examined in human breast tumors, breast cancer cell lines, and adipose stromal cells, by means of reverse transcription polymerase chain reaction amplification. Of the six breast tumor samples examined, all expressed transcripts encoding IL-6 and Leukemia Inhibitory Factor (LIF). Four of the samples also expressed transcripts for oncostatin M (OSM) and IL-11, and three expressed the IL-6 receptor. Adi...
110 Citations Source Cite
Alexandros N. Vgontzas60
Estimated H-index: 60
(Pennsylvania State University),
Dimitris A. Papanicolaou31
Estimated H-index: 31
(National Institutes of Health)
+ 3 AuthorsGeorge P. Chrousos147
Estimated H-index: 147
(National Institutes of Health)
Excessive daytime sleepiness (EDS) and fatigue are frequent symptoms in the general population and the chief complaint of the majority of patients at Sleep Disorders Centers. There is evidence that the inflammatory cytokines tumor necrosis factor-α (TNFα), interleukin-1β (IL-1β), and IL-6 are involved in physiological sleep regulation and that their administration to humans is associated with sleepiness and fatigue. To explore whether plasma levels of TNFα, IL-1β, and IL-6 are elevated in patien...
728 Citations Source Cite
Published on Sep 1, 1995in Journal of Hepatology 15.04
Anke M.B.C. Tiggelman4
Estimated H-index: 4
(University of Amsterdam),
Willem Boers12
Estimated H-index: 12
(University of Amsterdam)
+ 3 AuthorsRobert A.E.M. Chamuleau3
Estimated H-index: 3
(University of Amsterdam)
Abstract Background/Aims: Interleukin-6 is a major trigger forthe synthesis of acute phase proteins by liver parenchymal cells. Acute phase proteins may contribute to the regulation of liver fibrosis by inhibition of proteases (e.g. collagenase) and by binding of cytokines. Since liver (myo)fibroblasts play an important role in the production of extracellular matrix in fibrotic livers, a study was undertaken into whether these cells are able to synthesize interleukin-6, which would give them the...
65 Citations Source Cite
Published on Aug 1, 1992in Metabolism-clinical and Experimental 5.96
Per Mårin18
Estimated H-index: 18
(University of Gothenburg),
Niklas Darin25
Estimated H-index: 25
(University of Gothenburg)
+ 3 AuthorsPer Björntorp33
Estimated H-index: 33
(University of Gothenburg)
Abstract Urinary cortisol output and serum cortisol concentrations were measured in the steady state, under “field” conditions, and during standardized inhibitory and stimulatory tests in premenopausal, obese women, and were analyzed in relation to adipose tissue distribution. Urinary cortisol output was increased under field conditions in women with an elevated waist to hip circumference ratio (WHR) and, in particular, in women with a large abdominal sagittal diameter, indicating visceral fat a...
417 Citations Source Cite
Cited By1346
Published on Jan 1, 2006in Acta medica Indonesiana
Ketut Suastika1
Estimated H-index: 1
Significant increase of obesity prevalence in almost all countries in the world recently has had obesity as a global health problem, and WHO in 1998 defined it as “the global epidemic”. Simply, obesity is defined as an excessive fat accumulation in fat tissue due to imbalance of energy intake and expenditure. Body mass index is a simple method for defining the degree of overweight and obesity, however, waist circumference is the preferred measure of abdominal obesity because it has greater relat...
13 Citations
Published on Jan 1, 2008
Palaniyandi Ravanan10
Estimated H-index: 10
,
Claude Rouch8
Estimated H-index: 8
,
Christian Lefebvre d'Hellencourt7
Estimated H-index: 7
1 Citations
Published on Jan 1, 2011in Advances in Cardiology
A. Lurie1
Estimated H-index: 1
The relationship between metabolic disorders and obstructive sleep apnea (OSA) is multidirectional. Obesity is recognized as the strongest risk factor for OSA. It is unknown whether metabolic syndrome
23 Citations Source Cite
Published on Jan 1, 2005
José-Manuel Fernández-Real32
Estimated H-index: 32
,
Wifredo Ricart48
Estimated H-index: 48
Globalization of the occidental way of life is leading to increasing prevalence of obesity and type 2 diabetes, the greatest pandemy of the xxi century. Type 2 diabetes is the result of concomitant peripheral insulin resistance and decreased β cell insulin secretion. In the last years, type 2 diabetes is increasingly recognized as an inflammatory state. Decreased insulin action was initially proposed as the triggering factor of the different components of the Metabolic Syndrome, which are direcl...
Source Cite
Published on Jan 1, 2013in Vitamins and Hormones Series 2.06
Gabriel Ángel Martos-Moreno15
Estimated H-index: 15
(Autonomous University of Madrid),
Vicente Barrios26
Estimated H-index: 26
(Instituto de Salud Carlos III)
+ 1 AuthorsJesús Argente43
Estimated H-index: 43
(Autonomous University of Madrid)
Abstract The worldwide increase in the prevalence of obesity in children and adolescents during the past decades, in addition to mounting evidence indicating that obesity is associated with an increased incidence of comorbidities and the risk of premature death, resulting in a high economical impact, has stimulated obesity-focused research. These studies have highlightened the prominent endocrine activity of adipose tissue, which is exerted through the synthesis and secretion of a wide variety o...
17 Citations Source Cite
Published on Jan 1, 2007
Daniel Edmundowicz35
Estimated H-index: 35
(University of Pittsburgh)
Obesity increases an individual’s risk for cardiovascular disease by causing a variety of cardiac structural changes, hemodynamic alterations, and metabolic dyscrasias that lead to both myocardial and endothelial dysfunction. Obesity is associated with an increase in both total blood volume and cardiac output due to the increased metabolic demands of excessive fat accumulation. This increased workload leads to an increased left ventricular mass and hypertrophy, which predispose to a clinically s...
Source Cite
Published on Jan 1, 2010
Emelia J. Benjamin2
Estimated H-index: 2
,
Peter W. F. Wilson28
Estimated H-index: 28
+ 6 AuthorsMartin G. Larson19
Estimated H-index: 19
Published on May 6, 2017in American Journal of Human Biology 1.57
Eunduck Park (University of Texas Health Science Center at Houston), Janet C. Meininger19
Estimated H-index: 19
(University of Texas Health Science Center at Houston)
+ 2 AuthorsNikhil S. Padhye10
Estimated H-index: 10
(University of Texas Health Science Center at Houston)
Objectives Cardiorespiratory fitness (fitness) has been inversely associated with inflammation, but whether the association is attributed to fitness itself or lower levels of adiposity remains uncertain in young adults. The purpose of this study was to determine the association of fitness and adiposity with inflammation in young adults. Methods A cross-sectional study was conducted with 88 participants aged 20–34 years. Fitness was assessed by a submaximal treadmill walking test. Adiposity was a...
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