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Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid

Published on Mar 1, 1998in The Journal of Clinical Endocrinology and Metabolism 5.79
· DOI :10.1210/jcem.83.3.4660
Susan K. Fried49
Estimated H-index: 49
,
Dove A. Bunkin1
Estimated H-index: 1
,
Andrew S. Greenberg68
Estimated H-index: 68
Abstract
The purpose of this study was to determine whether human adipocytes from different depots of obese subjects produce interleukin-6 (IL-6) and whether IL-6 release is regulated by glucocorticoids. Fragments of omental and abdominal sc adipose tissue released immunodetectable IL-6 into the medium during acute incubations. Omental adipose tissue released 2–3 times more IL-6 than did sc adipose tissue. Isolated adipocytes prepared from these tissues also released IL-6 (omental> sc), but this accounted for only 10% of the total tissue release. Culture of adipose tissue fragments for 7 days with the glucocorticoid dexamethasone markedly suppressed IL-6 production. These data show for the first time that substantial quantities of IL-6 (up to 75 ng/mL) accumulate in the medium during incubations of both adipocytes and adipose tissue. Although little is known about the effects of IL-6 on adipose tissue, one action is a down-regulation of adipose tissue lipoprotein lipase. The regulated production of this multifunct...
  • References (34)
  • Citations (1363)
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References34
Newest
Günter Päth3
Estimated H-index: 3
(Leipzig University),
Stefan R. Bornstein79
Estimated H-index: 79
(Leipzig University)
+ 1 AuthorsWerner A. Scherbaum41
Estimated H-index: 41
(Leipzig University)
Interleukin (IL)-6 is a potent activator of the human hypothalamic-pituitary-adrenal axis. After chronic administration of IL-6 in humans, there is a substantial elevation of cortisol, whereas ACTH levels are blunted. Thus, we investigated whether IL-6 and/or the IL-6 receptor (IL-6R) are expressed in the human adrenal gland and whether IL-6 could cause the release of steroid hormones by a direct action on adrenal cells in primary culture. The expression of IL-6 and IL-6R was investigated with R...
145 Citations Source Cite
Junichi Hirokawa7
Estimated H-index: 7
(Hokkaido University),
Shinji Sakaue15
Estimated H-index: 15
(Hokkaido University)
+ 4 AuthorsJun Nishihira53
Estimated H-index: 53
(Hokkaido University)
Macrophage migration inhibitory factor (MIF) has been rediscovered as a proinflammatory cytokine, pituitary hormone, and glucocorticoid-induced immunoregulator. A survey of tissue distribution revealed that MIF expression is not limited to T lymphocytes, but exists in several other tissues; however, its presence in adipose tissue has never been investigated. In this study, we examined the expression of MIF in adipose tissue using the rat epididymal fat pad and murine 3T3-L1 adipocytes. Northern ...
79 Citations Source Cite
Alexandros N. Vgontzas61
Estimated H-index: 61
(Pennsylvania State University),
Dimitris A. Papanicolaou33
Estimated H-index: 33
(National Institutes of Health)
+ 3 AuthorsGeorge P. Chrousos150
Estimated H-index: 150
(National Institutes of Health)
Excessive daytime sleepiness (EDS) and fatigue are frequent symptoms in the general population and the chief complaint of the majority of patients at Sleep Disorders Centers. There is evidence that the inflammatory cytokines tumor necrosis factor-α (TNFα), interleukin-1β (IL-1β), and IL-6 are involved in physiological sleep regulation and that their administration to humans is associated with sleepiness and fatigue. To explore whether plasma levels of TNFα, IL-1β, and IL-6 are elevated in patien...
731 Citations Source Cite
Published on May 1, 1997in Endocrinology 3.96
Matthias M. Weber20
Estimated H-index: 20
(Ludwig Maximilian University of Munich),
P. Michl2
Estimated H-index: 2
(Ludwig Maximilian University of Munich)
+ 1 AuthorsDieterEngelhardt19
Estimated H-index: 19
(Ludwig Maximilian University of Munich)
Accumulating data indicate that interleukins can activate the hypothalamic-pituitary-adrenal (HPA) axis. We evaluated the effect of human recombinant interleukin-3 (IL-3) and interleukin-6 (IL-6) on cortisol secretion from adult human adrenocortical cells in primary culture. IL-3 and IL-6 (100 μg/L) equipotently stimulated basal cortisol secretion approximately 5-fold. The stimulatory effect was significant after 12 h (p < 0.01) and maximum cortisol levels were induced after 48 h. In contrast to...
65 Citations Source Cite
Corinne Cudicini2
Estimated H-index: 2
(University of Rennes),
Hervé Lejeune29
Estimated H-index: 29
(French Institute of Health and Medical Research)
+ 4 AuthorsBernard Jégou50
Estimated H-index: 50
(University of Rennes)
Interleukins (IL)-1 and -6 have been shown to be produced by several categories of cells in the rat testis and involved in the paracrine control of testicular function. Evidence of high amounts of IL-1 have been shown in the human testis, but nothing is known about its cellular origin. Furthermore, to our knowledge, the presence of IL-6 in the human testis has not yet been investigated. Therefore, the present study was aimed at identifying IL-1 and -6 expression and production within the human t...
99 Citations Source Cite
Published on Apr 18, 1997in Journal of Biological Chemistry 4.01
Günter Müller29
Estimated H-index: 29
,
Johann Ertl1
Estimated H-index: 1
+ 1 AuthorsGerald Preibisch4
Estimated H-index: 4
Abstract Leptin is an adipocyte hormone involved in the regulation of energy homeostasis. Generally accepted biological effects of leptin are inhibition of food intake and stimulation of metabolic rate in ob/ob mice that are defective in the leptin gene. In contrast to these centrally mediated effects of leptin, we are reporting here on leptin effects on isolated rat adipocytes. Leptin impairs several metabolic actions of insulin, i.e.stimulation of glucose transport, glycogen synthase, lipogene...
397 Citations Source Cite
Published on Apr 1, 1997in Annual Review of Immunology 22.71
Tetsuya Taga9
Estimated H-index: 9
,
Tadamitsukishimoto164
Estimated H-index: 164
▪ Abstract Receptors for most interleukins and cytokines that regulate immune and hematopoietic systems belong to the class I cytokine receptor family. These molecules form multichain receptor complexes in order to exhibit high-affinity binding to, and mediate biological functions of, their respective cytokines. In most cases, these functional receptor complexes share common signal transducing receptor components that are also in the class I cytokine receptor family, i.e. gp130, common β, and co...
1,269 Citations Source Cite
Osamu Kozawa34
Estimated H-index: 34
(Gifu University),
A. Suzuki1
Estimated H-index: 1
(Gifu University)
+ 1 AuthorsToshihiko Uematsu31
Estimated H-index: 31
(Gifu University)
In previous studies, we reported that prostaglandin F2alpha (PGF2alpha) stimulates phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D in osteoblast-like MC3T3-E1 cells. In the present study, we examined the effect of PGF2alpha on synthesis of interleukin-6 (IL-6) and the involvement of protein kinase C (PKC) activation in the IL-6 synthesis in these cells. PGF2alpha significantly stimulated IL-6 synthesis in a dose-dependent manner in the range b...
39 Citations Source Cite
Published on Jan 1, 1997in Molecular Medicine 3.34
Fahumiya Samad15
Estimated H-index: 15
(Scripps Research Institute),
Koji Yamamoto4
Estimated H-index: 4
(Scripps Research Institute)
+ 1 AuthorsDavid J. Loskutoff80
Estimated H-index: 80
(Scripps Research Institute)
Tumor necrosis factor-α (TNF-α) is chronically elevated in the adipose tissue from obese humans and mice. This increase in TNF-α contributes to the insulin resistance, elevated plasminogen activator inhibitor-1 (PAI-1) levels, and cardiovascular complications associated with obesity and noninsulin-dependent diabetes (NIDDM). PAI-1 gene expression in adipose tissue is also stimulated by transforming growth factor-β (TGF-β). Experiments were performed to determine whether TGF-β is regulated by TNF...
218 Citations Source Cite
Published on Dec 1, 1996in Cytokine & Growth Factor Reviews 6.39
Douglas L. Mann81
Estimated H-index: 81
(Baylor College of Medicine)
Abstract The ability of myocardium to successfully compensate for, and adapt to, stress ultimately determines whether the heart will decompensate and fail, or whether it will instead maintain preserved function. Despite the importance of the myocardial response to environmental stress, very little is known with respect to the biochemical mechanisms that are responsible for mediating and integrating the stress response in the heart. In the present review we will summarize recent experimental mate...
98 Citations Source Cite
Cited By1363
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Published on Feb 6, 2019in Scientific Reports 4.12
Alexis M. Temkin2
Estimated H-index: 2
(Medical University of South Carolina),
Robert R. Bowers6
Estimated H-index: 6
(Medical University of South Carolina)
+ 5 AuthorsDemetri D. Spyropoulos18
Estimated H-index: 18
(Medical University of South Carolina)
Evidence indicates that obesity can be promoted by chemical ‘obesogens’ that drive adiposity, hunger, inflammation and suppress metabolism. Dioctyl sodium sulfosuccinate (DOSS), a lipid emulsifier and candidate obesogen in vitro, is widely used in processed foods, cosmetics and as stool softener medicines commonly used during pregnancy. In vivo testing of DOSS was performed in a developmental origins of adult obesity model. Pregnant mice were orally administered vehicle control or DOSS at times ...
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Published on Aug 1, 2019in Cytokine 3.51
Ruma G. Singh8
Estimated H-index: 8
,
Ngoc Nhu Nguyen1
Estimated H-index: 1
+ 3 AuthorsMaxim S. Petrov23
Estimated H-index: 23
Source Cite
Published on Oct 9, 2018in International Journal of Obesity 5.16
D. Kumar10
Estimated H-index: 10
(Academy of Scientific and Innovative Research),
Sanket Pandya3
Estimated H-index: 3
(Academy of Scientific and Innovative Research)
+ 8 AuthorsAmit Misra19
Estimated H-index: 19
(Central Drug Research Institute)
Chronic low-grade inflammation/meta-inflammation in adipose tissue leads to obesity-associated metabolic complications. Despite growing understanding, the roles of immune cell subsets, their interrelationship, and chronological events leading to progression of obesity-associated insulin resistance (IR) remains unclear. We carried out temporal immunometabolic profiling of adipose tissue from C57BL/6 mice fed a high-fat diet (HFD) for 4, 8, 12, 16, and 20 weeks. We used clodronate sodium liposomes...
3 Citations Source Cite
Published on May 16, 2019in Aesthetic Surgery Journal 2.82
Francisco Claro3
Estimated H-index: 3
(State University of Campinas),
Joseane Morari20
Estimated H-index: 20
(State University of Campinas)
+ 2 AuthorsLício A. Velloso59
Estimated H-index: 59
(State University of Campinas)
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Published on May 2, 2019in Experimental Diabetes Research
Daisuke Murakami (Kyushu University), Futoshi Anan18
Estimated H-index: 18
+ 4 AuthorsTakashi Nakagawa (Kyushu University)
Objective. The number of patients with type 2 diabetes has increased in Japan, and type 2 diabetes has attracted attention as a risk factor for asthma. However, the risk factors for the development of asthma in patients with type 2 diabetes have not been determined. This study was performed to clarify whether visceral fat accumulation (VFA) and insulin resistance are risk factors for the development of asthma in patients with type 2 diabetes. Materials and Methods. A cross-sectional study was co...
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Published on Apr 21, 2019in British Journal of Pharmacology 6.81
Darren C. Henstridge (RMIT University), Julie Abildgaard4
Estimated H-index: 4
(University of Copenhagen)
+ 1 AuthorsMark A. Febbraio84
Estimated H-index: 84
(Garvan Institute of Medical Research)
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Published on Apr 17, 2019in Carcinogenesis 5.07
Qinchuan Wang1
Estimated H-index: 1
(Zhejiang University),
Huakang Tu3
Estimated H-index: 3
(University of Texas MD Anderson Cancer Center)
+ 5 AuthorsXifeng Wu (Zhejiang University)
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Published on Apr 16, 2019in Nutrition and Health
Matthew Christensen1
Estimated H-index: 1
(University of Northern Colorado),
Peter Smoak1
Estimated H-index: 1
(University of Northern Colorado)
+ 5 AuthorsLaura K. Stewart18
Estimated H-index: 18
(University of Northern Colorado)
Background:The control of chronic inflammation has emerged as a target for improving the health of cancer survivors (CS).Aim:To examine differences in fitness and dietary characteristics of CS when grouped by low vs. moderate to high serum C-reactive protein (CRP).Methods:CS (N = 26, mean age = 68 ± 12 years) were evaluated for body mass index (BMI), body composition, cardiorespiratory fitness, dietary intake, dietary inflammatory index (DII), and serum CRP. Participants were assigned to one of ...
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