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The Role of Social Media in Recruiting for Clinical Trials in Pregnancy

Published on Mar 26, 2014in PLOS ONE 2.78
· DOI :10.1371/journal.pone.0092744
Mahvash Shere3
Estimated H-index: 3
(U of T: University of Toronto),
Xiu Yan Zhao1
Estimated H-index: 1
Gideon Koren83
Estimated H-index: 83
(U of T: University of Toronto)
Background Recruitment of women in the periconceptional period to clinical studies using traditional advertising through medical establishments is difficult and slow. Given the widespread use of the internet as a source for medical information and research, we analyze the impact of social media in the second phase of an ongoing randomized, open-label clinical trial among pregnant women. This study aims to assess the effectiveness of social media as a recruitment tool through the comparison of diverse recruitment techniques in two different phases of the trial. Methods Recruitment in Phase 1 of the study consisted solely of traditional healthcare-based sources. This was compared to Phase 2 of the study where traditional recruitment was continued and expanded, while social media was used as a supplementary source. Yearly recruitment and recruitment rates in the two phases were compared using the Mann Whitney U test. The contributions of each recruitment source to overall recruitment were analyzed, and the impact of potential confounders on recruitment rate was evaluated using a multiple regression and Interrupted Time Series Analysis. Results In the first phase of the study, with over 56 months of recruitment using traditional sources, 35 women were enrolled in the study, resulting in a mean rate of ±0.62 recruits/month. In the 6 months implementing recruitment through social media, 45 women were recruited, for a 12-fold higher rate of ±7.5 recruits/month. Attrition rates remained constant, suggesting that social media had a positive impact on recruitment. The Interrupted Time Series Analysis detected a significant difference in recruitment after the intervention of social media (p<0.0001) with an evident increase in the number of recruits observed after the use of social media. Conclusions Clinicians and scientists recruiting for clinical studies should learn how to use online social media platforms to improve recruitment rates, thus increasing recruitment efficiency and cost-effectiveness.
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Published on Jan 1, 2012in Fertility and Sterility 5.41
Kenan Omurtag8
Estimated H-index: 8
(WashU: Washington University in St. Louis),
Patricia T. Jimenez3
Estimated H-index: 3
(WashU: Washington University in St. Louis)
+ 2 AuthorsAmber R. Cooper8
Estimated H-index: 8
(WashU: Washington University in St. Louis)
Objective To study and describe the use of social networking websites among Society for Assisted Reproductive Technology (SART) member clinics. Design Cross-sectional study. Setting University-based practice. Patient(s) Not applicable. Intervention(s) Not applicable. Main Outcome Measure(s) Prevalence of social networking websites among SART member clinics and evaluation of content, volume, and location (i.e., mandated state, region) using multivariate regression analysis. Result(s) A total of 3...
23 Citations Source Cite
Published on Apr 14, 2010in Cochrane Database of Systematic Reviews 7.75
Shaun Treweek34
Estimated H-index: 34
(Dund.: University of Dundee),
Elizabeth Mitchell16
Estimated H-index: 16
(Dund.: University of Dundee)
+ 8 AuthorsCatherine Jackson19
Estimated H-index: 19
(St And: University of St Andrews)
Background Recruiting participants to trials can be extremely difficult. Identifying strategies that improve trial recruitment would benefit both trialists and health research. Objectives To quantify the effects of strategies to improve recruitment of participants to randomised controlled trials. Search methods We searched the Cochrane Methodology Review Group Specialised Register (CMR) 2010, Issue 2, part of The Cochrane Library (online) (searched 16 April 2010); MEDL...
244 Citations Source Cite
Published on Dec 1, 2008in BMC Pregnancy and Childbirth 2.41
Rebecca Tooher14
Estimated H-index: 14
(University of Adelaide),
Philippa Middleton45
Estimated H-index: 45
(University of Adelaide),
Caroline A Crowther60
Estimated H-index: 60
(University of Adelaide)
Abstract Background Recruitment of eligible participants remains one of the biggest challenges to successful completion of randomised controlled trials (RCTs). Only one third of trials recruit on time, often requiring a lengthy extension to the recruitment period. We identified factors influencing recruitment success and potentially effective recruitment strategies. Methods We searched MEDLINE and EMBASE from 1966 to December Week 2, 2006, the Cochrane Library Methodology Register in December 20...
45 Citations Source Cite
Published on May 1, 2008in Womens Health Issues 1.96
Diana L. Velott9
Estimated H-index: 9
(PSU: Pennsylvania State University),
Sara A. Baker3
Estimated H-index: 3
(PSU: Pennsylvania State University)
+ 1 AuthorsWeismanCarolS42
Estimated H-index: 42
(PSU: Pennsylvania State University)
Background Community-based health studies rely on the ability of researchers to successfully recruit and retain participants from target populations, rather than from clinical settings. Many prior women's health studies have recruited in urban and suburban areas, but rural populations pose specific challenges. We describe the recruitment strategies employed in the Central Pennsylvania Women's Health Study to recruit 692 women in 15 low-income rural communities to a randomized trial of a behavior...
19 Citations Source Cite
Published on Dec 1, 2006in BMC Medical Research Methodology 2.51
Judith Watson14
Estimated H-index: 14
(Ebor: University of York),
David Tappin74
Estimated H-index: 74
(Ebor: University of York)
Background Poor recruitment to randomised controlled trials (RCTs) is a widespread and important problem. With poor recruitment being such an important issue with respect to the conduct of randomised trials, a systematic review of controlled trials on recruitment methods was undertaken in order to identify strategies that are effective.
200 Citations Source Cite
Published on Nov 1, 2006in Paediatric and Perinatal Epidemiology 2.68
Cecilia Pyper1
Estimated H-index: 1
Lise Bromhall1
Estimated H-index: 1
+ 3 AuthorsMichael F. Murphy56
Estimated H-index: 56
(University of Oxford)
Summary The Oxford Conception Study is a randomised controlled trial that aims to determine whether or not information about potential fertility from a device that monitors urinary hormones will increase the conception rate in women wishing to conceive. Three modified versions of a fertility monitor have been developed for the study. The monitor measures the levels of urinary oestrone-3-glucuronide (E3G) and luteinising hormone (LH), and the display indicates high or low fertility. The monitor r...
22 Citations Source Cite
Published on Apr 1, 2006in Quality & Safety in Health Care
Sara Kenyon24
Estimated H-index: 24
Mary Dixon-Woods51
Estimated H-index: 51
(University of Leicester)
+ 2 AuthorsEmma Pitchforth20
Estimated H-index: 20
Background: Randomised controlled trials of interventions in critical situations are necessary to establish safety and evaluate outcomes. Pregnant women have been identified as a potentially vulnerable population. Objective: To explore women’s experiences of being recruited to ORACLE, a randomised controlled trial of antibiotics in pre-term labour. Methods: Twenty qualitative interviews were conducted with women who had participated in ORACLE. Analysis was based on the constant comparative metho...
41 Citations Source Cite
Published on Jul 22, 2002in Cochrane Database of Systematic Reviews 7.75
James Mapstone10
Estimated H-index: 10
Diana Elbourne54
Estimated H-index: 54
(Lond: University of London),
Ian Roberts Mbbch79
Estimated H-index: 79
(Lond: University of London)
Background Research studies are essential to improving healthcare. However, many fail to recruit their planned number of participants. There are many interventions that researchers try to improve recruitment. Finding which ones are effective would be of benefit to the research community and society. Objectives To quantify the effects of strategies to improve participation in research studies. Search methods We aimed to find all randomized and quasi-randomized controlled trials of strategies to i...
163 Citations Source Cite
Cited By30
Published on May 6, 2019in Clinical Trials 2.26
Katherine A. Guthrie38
Estimated H-index: 38
(Fred Hutchinson Cancer Research Center),
Bette J. Caan76
Estimated H-index: 76
(KP: Kaiser Permanente)
+ 6 AuthorsAndrea Z. LaCroix96
Estimated H-index: 96
(UCSD: University of California, San Diego)
BackgroundThe MsFLASH (Menopause Strategies: Finding Lasting Answers for Symptoms and Health) Network recruited into five randomized clinical trials (n = 100–350) through mass mailings. The fifth trial tested two interventions for postmenopausal vulvovaginal symptoms (itching, pain, irritation, dryness, or pain with sex) and thus required a high level of sensitivity to privacy concerns. For this trial, in addition to mass mailings we pilot tested a social media recruitment approach. We aimed to ...
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Published on Jan 1, 2019in Western Journal of Nursing Research 1.46
Yehudis Stokes2
Estimated H-index: 2
(U of O: University of Ottawa),
Amanda Digel Vandyk6
Estimated H-index: 6
(U of O: University of Ottawa)
+ 2 AuthorsWendy Gifford12
Estimated H-index: 12
(U of O: University of Ottawa)
Social media is an emerging tool used by researchers; however, limited information is available on its use for participant recruitment specifically. The purpose of this article is to describe the use of Facebook and LinkedIn social media sites in the recruitment of nurses for an online survey, using a 5-week modified online Dillman approach. Within 3 weeks, we exceeded our target sample size (n = 170) and within 5 weeks recruited 267 English-speaking nurses (n = 172, Facebook; n = 95, LinkedIn)....
1 Citations Source Cite
Published on Dec 1, 2018in Trials 1.98
Mahalakshmi Ekambareshwar (USYD: University of Sydney), Seema Mihrshahi26
Estimated H-index: 26
(USYD: University of Sydney)
+ 4 AuthorsChris Rissel47
Estimated H-index: 47
Recruitment of pregnant women into trials is a challenge exacerbated by a number of factors, including strict eligibility criteria. There has been little in-depth examination of the recruitment process to trials involving pregnant women. This paper presents the findings of a study conducted to identify facilitators and challenges in recruiting pregnant women to the Communicating Healthy Beginnings Advice by Telephone (CHAT) randomised controlled trial, which aims to reduce the prevalence of infa...
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Published on Oct 1, 2018in Journal of Advanced Nursing 2.38
Graham R. Williamson18
Estimated H-index: 18
(Plymouth University),
Anita O'Connor (Plymouth University)+ 1 AuthorsDavid Halpin24
Estimated H-index: 24
(RD&E: Royal Devon and Exeter Hospital)
1 Citations Source Cite
Published on Mar 1, 2018in Hispanic Health Care International
Rosamar Torres1
Estimated H-index: 1
(UCLA: University of California, Los Angeles),
Priscilla Kehoe27
Estimated H-index: 27
(UCI: University of California, Irvine),
MarySue V. Heilemann15
Estimated H-index: 15
(UCLA: University of California, Los Angeles)
Introduction:Little is known of late adolescent Texas Latinas’ prenatal care perceptions or how these perceptions predict timely prenatal care initiation or adequate utilization. Hence, the purpose of this study is to describe and compare these perceptions between participants with timely versus late prenatal care initiation and adequate, intermediate, and inadequate prenatal care utilization; and to determine predictors of timely prenatal care initiation and adequate utilization.Methods:Fifty-f...
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Published on Jan 1, 2018
Saliha Akhtar (Seton Hall University)
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Published on Nov 3, 2017in JMIR Research Protocols
Kristopher J Abbate1
Estimated H-index: 1
Melanie D Hingle19
Estimated H-index: 19
+ 2 AuthorsJudith S. Gordon23
Estimated H-index: 23
Background: Successful recruitment of participants to mobile health (mHealth) studies presents unique challenges over in-person studies. It is important to identify recruitment strategies that maximize the limited recruitment resources available to researchers. Objective: The objective of this study was to describe a case study of a unique recruitment process used in a recent mHealth software app designed to increase smoking cessation among weight-concerned women smokers. The See Me Smoke-Free a...
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Published on Oct 24, 2017in JMIR Research Protocols
Jacqueline D. Burgess4
Estimated H-index: 4
Rebecca M. N. Kimble Mbbs Franzcog34
Estimated H-index: 34
+ 1 AuthorsCate M. Cameron10
Estimated H-index: 10
Background: Using social media to recruit specific populations for research studies is gaining popularity. Given that mothers of young children are the most active on social media, and young children are the most at risk of preventable burn injuries, social media was used to recruit mothers of young children to a burn prevention intervention. Objective: The aim of this paper was to describe the social media recruitment methods used to enroll mothers of young children to the app-based burn preven...
3 Citations Source Cite