Multiplex Genome Engineering Using CRISPR/Cas Systems
Abstract
Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune system has been shown to facilitate RNA-guided site-specific DNA cleavage. We engineered two different type II CRISPR/Cas systems and demonstrate that Cas9 nucleases can be directed by short RNAs to induce precise cleavage at...
Paper Details
Title
Multiplex Genome Engineering Using CRISPR/Cas Systems
Published Date
Feb 15, 2013
Journal
Volume
339
Issue
6121
Pages
819 - 823
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