Effects of sibutramine on abdominal fat mass, insulin resistance and blood pressure in obese hypertensive patients

Objective: The objective of this study is to assess the effects of sibutramine on body weight, body fat distribution, insulin resistance, plasma leptin, lipid profile and blood pressure profiles in hypertensive obese patients. Methods: Eighty‐six central obese hypertensive patients (BMI = 39 ± 5 kg/m 2 , 84% of women, 48 ± 8.5 years old) were placed on a hypocaloric diet and placebo therapy for 4 weeks. They were then randomized to receive...