Inhibition of BMP signaling suppresses metastasis in mammary cancer

Volume: 34, Issue: 19, Pages: 2437 - 2449
Published: May 7, 2015
Abstract
Bone morphogenetic proteins (BMPs) are secreted cytokines/growth factors that have differing roles in cancer. BMPs are overexpressed in human breast cancers, but loss of BMP signaling in mammary carcinomas can accelerate metastasis. We show that human breast cancers display active BMP signaling, which is rarely downregulated or homozygously deleted. We hypothesized that systemic inhibition of BMP signaling in both the tumor and the surrounding...
Paper Details
Title
Inhibition of BMP signaling suppresses metastasis in mammary cancer
Published Date
May 7, 2015
Journal
Volume
34
Issue
19
Pages
2437 - 2449
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