SIRT1 in cardiovascular aging
Abstract
Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD+-dependent histone deacetylase, is closely related to lifespan extension. SIRT1 exerts beneficial effects on aging and age-related diseases, such as atherosclerosis. In this review, we summarize the current knowledge on the functions of SIRT1 in...
Paper Details
Title
SIRT1 in cardiovascular aging
Published Date
Nov 1, 2014
Journal
Volume
437
Pages
106 - 114
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