Match!

How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study

Published on Dec 1, 2008in Psychological Medicine5.641
· DOI :10.1017/S0033291708003115
Barry J. Milne31
Estimated H-index: 31
('KCL': King's College London),
Terrie E. Moffitt161
Estimated H-index: 161
('KCL': King's College London)
+ 5 AuthorsAvshalom Caspi150
Estimated H-index: 150
('KCL': King's College London)
Abstract
Background. There is increased interest in assessing the family history of psychiatric disorders for both genetic research and public health screening. It is unclear how best to combine family history reports into an overall score. We compare the predictive validity of different family history scores. Method. Probands from the Dunedin Study (n=981, 51% male) had their family history assessed for nine different conditions. We computed four family history scores for each disorder: (1) a simple dichotomous categorization of whether or not probands had any disordered first-degree relatives; (2) the observed number of disordered first-degree relatives; (3) the proportion of first-degree relatives who are disordered; and (4) Reed's score, which expressed the observed number of disordered first-degree relatives in terms of the number expected given the age and sex of each relative. We compared the strength of association between each family history score and probands' disorder outcome. Results. Each score produced significant family history associations for all disorders. The scores that took account of the number of disordered relatives within families (i.e. the observed, proportion, and Reed's scores) produced significantly stronger associations than the dichotomous score for conduct disorder, alcohol dependence and smoking. Taking account of family size (i.e. using the proportion or Reed's score) produced stronger family history associations depending on the prevalence of the disorder among family members. Conclusions. Dichotomous family history scores can be improved upon by considering the number of disordered relatives in a family and the population prevalence of the disorder.
  • References (48)
  • Citations (42)
📖 Papers frequently viewed together
377 Citations
303 Citations
168 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References48
Newest
#2Stéphane Rothen (CHUV: University Hospital of Lausanne)H-Index: 15
Last. Martin Preisig (CHUV: University Hospital of Lausanne)H-Index: 48
view all 11 authors...
Abstract Objectives Family studies typically use multiple sources of information on each individual including direct interviews and family history information. The aims of the present study were to: (1) assess agreement for diagnoses of specific substance use disorders between direct interviews and the family history method; (2) compare prevalence estimates according to the two methods; (3) test strategies to approximate prevalence estimates according to family history reports to those based on ...
24 CitationsSource
#1Havi Murad (Sheba Medical Center)H-Index: 15
#2Ofra Kalter-Leibovici (Sheba Medical Center)H-Index: 22
Last. Laurence S. Freedman (Sheba Medical Center)H-Index: 52
view all 4 authors...
Family history (FH) scores are used for estimating the familial risk (FR), i.e. the level of risk for a particular disease among members of that family. An FH score is created from reports about the disease status of the relatives in each family. The most commonly used score is the dichotomous score (positive when at least one relative is affected), which does not consider the family size, number of affected relatives nor each relative's risk factor profile. Authors have proposed many other FH s...
10 CitationsSource
#1Terrie E. Moffitt (University of Cambridge)H-Index: 161
#2HonaLee Harrington (UW: University of Wisconsin-Madison)H-Index: 24
Last. Richie Poulton (University of Otago)H-Index: 90
view all 7 authors...
Context The close association between generalized anxiety disorder (GAD) and major depressive disorder (MDD) prompts questions about how to characterize this association in future diagnostic systems. Most information about GAD-MDD comorbidity comes from patient samples and retrospective surveys. Objective To revisit the sequential and cumulative comorbidity between GAD and MDD using data from a prospective longitudinal cohort. Design Prospective longitudinal cohort study. Setting New Zealand. Pa...
388 CitationsSource
#1Helen Coelho (University of Reading)H-Index: 15
#2Peter J. Cooper (University of Reading)H-Index: 63
Last. Lynne Murray (University of Reading)H-Index: 67
view all 3 authors...
Abstract Background High rates of co-morbidity between Generalized Social Phobia (GSP) and Generalized Anxiety Disorder (GAD) have been documented. The reason for this is unclear. Family studies are one means of clarifying the nature of co-morbidity between two disorders. Methods Six models of co-morbidity between GSP and GAD were investigated in a family aggregation study of 403 first-degree relatives of non-clinical probands: 37 with GSP, 22 with GAD, 15 with co-morbid GSP/GAD, and 41 controls...
20 CitationsSource
#1Xiangning ChenH-Index: 37
#2Xu Wang (VCU: Virginia Commonwealth University)H-Index: 11
Last. Kenneth S. Kendler (VCU: Virginia Commonwealth University)H-Index: 161
view all 8 authors...
Chromosome 5q21–33 has been implicated in harboring risk genes for schizophrenia. In this paper, we report evidence that multiple single nucleotide polymorphisms in and around interleukin 3 (IL3) are associated with the disease in the Irish Study of High-Density Schizophrenia Families (ISHDSF), the Irish Case–Control Study of Schizophrenia (ICCSS) and the Irish Trio Study of Schizophrenia (ITRIO). The associations are sex-specific and depend on the family history (FH) of schizophrenia. In all th...
45 CitationsSource
#1Jochen Hardt (HHU: University of Düsseldorf)H-Index: 37
#2Petra Franke (HHU: University of Düsseldorf)H-Index: 33
Abstract Background The family history is a widely used method in psychiatry; but data on the method's objectivity, reliability and validity shows partly diverging results. Method In October 2005, a Medline search was conducted that yielded 7 studies regarding objectivity/reliability and 13 studies regarding validity. Results for six main groups of psychiatric diagnoses and any mental disorder were combined qualitatively for objectivity/reliability, and quantitatively for validity. Results Objec...
33 CitationsSource
#1Stephen C. Newman (U of A: University of Alberta)H-Index: 40
#2Roger C. Bland (U of A: University of Alberta)H-Index: 43
Background. A recent meta-analysis provides evidence that generalized anxiety disorder (GAD) is familial. However, two of the key studies relied on subjects who were self-selected or recruited from the clinic setting, thereby limiting generalizability. Method. We conducted a family study of GAD in which probands and controls came from a community sample originally enrolled in a prevalence study in Edmonton, Canada. One hundred and sixty probands, 764 controls and 2386 first-degree relatives (FDR...
14 CitationsSource
#1Helen CoelhoH-Index: 15
#2Peter J. CooperH-Index: 63
Last. Lynne MurrayH-Index: 67
view all 3 authors...
Previous studies have suggested that collecting psychiatric data on relatives in family studies by asking probands to provide information on them leads to a bias in estimates of morbidity risk, because probands' accounts are influenced by their own psychiatric histories. We investigated this in a UK sample and found that daughters' anxiety disorder histories did not influence their reports of anxiety disorder in mothers, but their history of mood disorder/alcohol dependence made them more sensit...
6 CitationsSource
#1Ping Qin (AU: Aarhus University)H-Index: 29
#2Huilan XuH-Index: 1
Last. Peter B. Mortensen (AU: Aarhus University)H-Index: 99
view all 5 authors...
Objectives To investigate whether age at onset of epilepsy, type of epilepsy, family history of psychosis, or family history of epilepsy affect the risk of schizophrenia or schizophrenia-like psychosis among patients with epilepsy. Design Comparison of population based data. Setting Danish longitudinal registers. Subjects The cohort comprised 2.27 million people. Main outcome measures Epilepsy, psychosis, personal birth data. Results We found an increased risk of schizophrenia (relative risk 2.4...
165 CitationsSource
#1Carol A. Prescott (VCU: Virginia Commonwealth University)H-Index: 66
#2Patrick F. SullivanH-Index: 110
Last. Kenneth S. Kendler (VCU: Virginia Commonwealth University)H-Index: 161
view all 8 authors...
Background: This article is the first report of the Irish Affected Sib Pair Study of Alcohol Dependence, whose goal is to detect the genomic location of susceptibility loci for alcohol dependence (AD). This article describes phenotypic characteristics of the probands, siblings, and parents included in the sample and examines agreement among different sources of diagnostic information, including the validity of family history (FH) assessment. Methods: Structured diagnostic interviews were conduct...
41 CitationsSource
Cited By42
Newest
#1Gayathri Pandey (SUNY Downstate Medical Center)H-Index: 1
#2Michael J. Seay (UCLA: University of California, Los Angeles)H-Index: 1
Last. Stacey Subbie Saenz de Viteri (SUNY Downstate Medical Center)H-Index: 1
view all 21 authors...
BACKGROUND: Family history (FH) is an important risk factor for the development of alcohol use disorder (AUD). A variety of dichotomous and density measures of FH have been used to predict alcohol outcomes; yet, a systematic comparison of these FH measures is lacking. We compared 4 density and 4 commonly used dichotomous FH measures and examined variations by gender and race/ethnicity in their associations with age of onset of regular drinking, parietal P3 amplitude to visual target, and likelih...
Source
#1Antonella Trotta ('KCL': King's College London)H-Index: 12
#2Louise Arseneault ('KCL': King's College London)H-Index: 55
Last. Helen L. Fisher ('KCL': King's College London)H-Index: 37
view all 7 authors...
Source
Source
#1Daniel Maughan (Oxford Health NHS Foundation Trust)
Source
#1Joanne Barbara Newbury ('KCL': King's College London)H-Index: 6
#2Louise Arseneault ('KCL': King's College London)H-Index: 55
Last. Helen L. Fisher ('KCL': King's College London)H-Index: 37
view all 8 authors...
Importance Urbanicity is a well-established risk factor for clinical (eg, schizophrenia) and subclinical (eg, hearing voices and paranoia) expressions of psychosis. To our knowledge, no studies have examined the association of air pollution with adolescent psychotic experiences, despite air pollution being a major environmental problem in cities. Objectives To examine the association between exposure to air pollution and adolescent psychotic experiences and test whether exposure mediates the ass...
9 CitationsSource
#1Elizabeth Prom-Wormley (VCU: Virginia Commonwealth University)H-Index: 15
#2James S. Clifford (VCU: Virginia Commonwealth University)H-Index: 4
Last. Cynthia NewbilleH-Index: 1
view all 14 authors...
Abstract Background Family history (FH) is an underutilized genetically informative tool that can influence disease prevention and treatment. It is unclear how FH fits into the development of community-based health education. This study examines the role that FH plays in perceived threat and health education related to mental and chronic physical conditions in the context of the health belief model. Methods Data were collected from 1,048 adult participants aged 18–90 years. Approximately 76% of ...
2 CitationsSource
#1Susanna Roberts ('KCL': King's College London)H-Index: 8
#2Louise Arseneault ('KCL': King's College London)H-Index: 55
Last. Helen L. Fisher ('KCL': King's College London)H-Index: 37
view all 10 authors...
Abstract Air pollution is a worldwide environmental health issue. Increasingly, reports suggest that poor air quality may be associated with mental health problems, but these studies often use global measures and rarely focus on early development when psychopathology commonly emerges. To address this, we combined high-resolution air pollution exposure estimates and prospectively-collected phenotypic data to explore concurrent and longitudinal associations between air pollutants of major concern ...
7 CitationsSource
#1Eloise Crush ('KCL': King's College London)H-Index: 2
#2Louise Arseneault ('KCL': King's College London)H-Index: 55
Last. Helen L. Fisher ('KCL': King's College London)H-Index: 37
view all 3 authors...
Purpose To investigate whether social support is protective for psychotic experiences similarly among poly-victimised adolescent girls and boys.
Source
#1Eloise Crush ('KCL': King's College London)H-Index: 2
#2Louise Arseneault ('KCL': King's College London)H-Index: 55
Last. Helen L. Fisher ('KCL': King's College London)H-Index: 37
view all 8 authors...
Abstract Experiencing multiple types of victimization (poly-victimization) during adolescence is associated with the onset of psychotic experiences (such as hearing voices, having visions, or being extremely paranoid). However, many poly-victimized adolescents will not develop such subclinical phenomena and the factors that protect them are unknown. This study investigated whether individual, family, or community-level characteristics were associated with an absence of psychotic experiences amon...
7 CitationsSource
#1Jasmin Wertz (Duke University)H-Index: 10
#2Avshalom CaspiH-Index: 150
Last. Terrie E. MoffittH-Index: 161
view all 16 authors...
Drawing on psychological and sociological theories of crime causation, we tested the hypothesis that genetic risk for low educational attainment (assessed via a genome-wide polygenic score) is asso...
10 CitationsSource