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How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study

Published on Dec 1, 2008in Psychological Medicine5.64
· DOI :10.1017/S0033291708003115
Barry John Milne31
Estimated H-index: 31
('KCL': King's College London),
Terrie E. Moffitt158
Estimated H-index: 158
('KCL': King's College London)
+ 5 AuthorsAvshalom Caspi146
Estimated H-index: 146
('KCL': King's College London)
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Abstract
Background. There is increased interest in assessing the family history of psychiatric disorders for both genetic research and public health screening. It is unclear how best to combine family history reports into an overall score. We compare the predictive validity of different family history scores. Method. Probands from the Dunedin Study (n=981, 51% male) had their family history assessed for nine different conditions. We computed four family history scores for each disorder: (1) a simple dichotomous categorization of whether or not probands had any disordered first-degree relatives; (2) the observed number of disordered first-degree relatives; (3) the proportion of first-degree relatives who are disordered; and (4) Reed's score, which expressed the observed number of disordered first-degree relatives in terms of the number expected given the age and sex of each relative. We compared the strength of association between each family history score and probands' disorder outcome. Results. Each score produced significant family history associations for all disorders. The scores that took account of the number of disordered relatives within families (i.e. the observed, proportion, and Reed's scores) produced significantly stronger associations than the dichotomous score for conduct disorder, alcohol dependence and smoking. Taking account of family size (i.e. using the proportion or Reed's score) produced stronger family history associations depending on the prevalence of the disorder among family members. Conclusions. Dichotomous family history scores can be improved upon by considering the number of disordered relatives in a family and the population prevalence of the disorder.
  • References (48)
  • Citations (39)
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References48
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#1Havi Murad (Sheba Medical Center)H-Index: 15
#2Ofra Kalter-Leibovici (Sheba Medical Center)H-Index: 17
Last.Laurence S. Freedman (Sheba Medical Center)H-Index: 60
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Cited By39
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#1Antonella Trotta ('KCL': King's College London)H-Index: 11
#2Louise Arseneault ('KCL': King's College London)H-Index: 54
Last.Helen L. Fisher ('KCL': King's College London)H-Index: 35
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#1Daniel Maughan (Oxford Health NHS Foundation Trust)
#1Joanne Barbara Newbury ('KCL': King's College London)H-Index: 4
#2Louise Arseneault ('KCL': King's College London)H-Index: 54
Last.Helen L. Fisher ('KCL': King's College London)H-Index: 35
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#1Elizabeth Prom-Wormley (VCU: Virginia Commonwealth University)H-Index: 15
#2James S. Clifford (VCU: Virginia Commonwealth University)H-Index: 4
Last.Alexis C. Edwards (VCU: Virginia Commonwealth University)H-Index: 12
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#1Eloise Crush ('KCL': King's College London)H-Index: 2
#2Louise Arseneault ('KCL': King's College London)H-Index: 54
Last.Helen L. Fisher ('KCL': King's College London)H-Index: 35
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View next paperBrief screening for family psychiatric history: the family history screen.