Effects of Angiotensin-Converting Enzyme Inhibition on Leptin and Adiponectin Levels in Essential Hypertension

Published on Jun 1, 2014in Basic & Clinical Pharmacology & Toxicology2.45
· DOI :10.1111/bcpt.12195
Vanessa Fontana14
Estimated H-index: 14
(State University of Campinas),
Ana Paula Faria10
Estimated H-index: 10
(State University of Campinas)
+ 4 AuthorsHeitor Moreno Junior31
Estimated H-index: 31
(State University of Campinas)
Activation of the renin-angiotensin-aldosterone system (RAAS) and abnormal adipokine levels are biological alterations that affect blood pressure regulation and interact to link hypertension, obesity and metabolic diseases. While imbalanced levels of hormones produced by adipocytes including hypo-adiponectinaemia and hyperleptinaemia were reported in hypertension, little is known about how antihypertensive therapy affects these alterations. This study aimed to evaluate the effects of enalapril on plasma adiponectin and leptin levels in hypertensive individuals. Thirty-seven untreated hypertensive patients were prospectively treated with enalapril for 8 weeks. Blood samples were collected at baseline and after the treatment with enalapril. Plasma adiponectin and leptin levels were measured by enzyme-linked immunoassay. We found significant increases in adiponectin levels after enalapril treatment (5.4 ± 3.7 versus 6.0 ± 4.5 μg/mL, mean±S.D., p = 0.04). Conversely, leptin levels were unchanged (18.0 ± 14.7 versus 18.4 ± 14.8 ng/mL, mean ± S.D., p = 0.31). Multiple linear regression revealed that baseline leptin is a significant predictor of systolic blood pressure reduction (β=0.269, p = 0.01) in hypertensive individuals treated with enalapril. While enalapril increases adiponectin levels in hypertensive individuals, baseline leptin levels predict blood pressure reduction in response to this therapy. These findings support the idea of an important relationship between RAAS and adipose tissue in hypertension and suggest that enalapril improves the adipokine profile, possibly allowing beneficial effects to overweight or obese hypertensive individuals.
  • References (35)
  • Citations (14)
#1Morena Scotece (Usach: University of Santiago, Chile)H-Index: 20
#2Javier Conde (Usach: University of Santiago, Chile)H-Index: 20
Last.Oreste Gualillo (Usach: University of Santiago, Chile)H-Index: 47
view all 7 authors...
#1Jintao Wang (UM: University of Michigan)H-Index: 6
#2Hui Wang (UM: University of Michigan)H-Index: 10
Last.Daniel T. Eitzman (UM: University of Michigan)H-Index: 33
view all 8 authors...
#1S. V. Nedogoda (The Volgograd State Medical University)H-Index: 2
#2Alla A. Ledyaeva (The Volgograd State Medical University)H-Index: 1
Last.Irina N. Barykina (The Volgograd State Medical University)H-Index: 2
view all 7 authors...
#1Eliete Dalla Corte Frantz (UERJ: Rio de Janeiro State University)H-Index: 7
#2Camila Crespo-Mascarenhas (UERJ: Rio de Janeiro State University)H-Index: 1
Last.Mandarim de Lacerda (UERJ: Rio de Janeiro State University)H-Index: 32
view all 5 authors...
#1Wenjuan Xing (Fourth Military Medical University)H-Index: 10
#2Wenjun Yan (Fourth Military Medical University)H-Index: 12
Last.Feng Gao (Fourth Military Medical University)H-Index: 31
view all 9 authors...
#1Vanessa Fontana (USP: University of São Paulo)H-Index: 14
#2Pamela S. Silva (State University of Campinas)H-Index: 8
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 34
view all 7 authors...
Cited By14
#1Shih-Jie Jhuo (KMU: Kaohsiung Medical University)H-Index: 3
#2Wei C. Tsai (KMU: Kaohsiung Medical University)H-Index: 9
Last.Wen-Ter Lai (KMU: Kaohsiung Medical University)H-Index: 22
view all 6 authors...
#1Marcelo R. Luizon (UFMG: Universidade Federal de Minas Gerais)H-Index: 3
#2Daniela A. Pereira (UFMG: Universidade Federal de Minas Gerais)H-Index: 1
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 34
view all 3 authors...
#1Beatriz Miralles (CSIC: Spanish National Research Council)H-Index: 21
#2Blanca Hernández-Ledesma (CSIC: Spanish National Research Council)H-Index: 28
Last.Isidra Recio (CSIC: Spanish National Research Council)H-Index: 47
view all 5 authors...
#1Gustavo H. Oliveira-Paula (USP: University of São Paulo)H-Index: 9
#2Riccardo Lacchini (USP: University of São Paulo)H-Index: 16
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 25
view all 3 authors...
View next paperRelationships among serum leptin,adiponectin and Renin-Angiotensin levels in patients with primary hypertension