Intrinsic coupling of lagging-strand synthesis to chromatin assembly
Abstract
Fifty per cent of the genome is discontinuously replicated on the lagging strand as Okazaki fragments. Eukaryotic Okazaki fragments remain poorly characterized and, because nucleosomes are rapidly deposited on nascent DNA, Okazaki fragment processing and nucleosome assembly potentially affect one another. Here we show that ligation-competent Okazaki fragments in Saccharomyces cerevisiae are sized according to the nucleosome repeat. Using deep...
Paper Details
Title
Intrinsic coupling of lagging-strand synthesis to chromatin assembly
Published Date
Mar 1, 2012
Journal
Volume
483
Issue
7390
Pages
434 - 438
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