Interactions of ?Ultra-Low? Doses of Naltrexone and Morphine in Mature and Young Male and Female Rats

Published: Mar 1, 2004
Abstract
Sex and age influence morphine analgesia in humans and animals. Mature rats show greater morphine analgesia in males than in females. Ultra-low doses of naltrexone enhance morphine analgesia. In mature rats (18-22 weeks), naltrexone (0.002-2.0 mg/kg)-morphine (2 mg/kg) cotreatment enhanced morphine analgesia in females, an effect inversely related to naltrexone dose. Conversely, in mature male rats, naltrexone tended to decrease morphine...
Paper Details
Title
Interactions of ?Ultra-Low? Doses of Naltrexone and Morphine in Mature and Young Male and Female Rats
Published Date
Mar 1, 2004
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