Interactions of ?Ultra-Low? Doses of Naltrexone and Morphine in Mature and Young Male and Female Rats
Abstract
Sex and age influence morphine analgesia in humans and animals. Mature rats show greater morphine analgesia in males than in females. Ultra-low doses of naltrexone enhance morphine analgesia. In mature rats (18-22 weeks), naltrexone (0.002-2.0 mg/kg)-morphine (2 mg/kg) cotreatment enhanced morphine analgesia in females, an effect inversely related to naltrexone dose. Conversely, in mature male rats, naltrexone tended to decrease morphine...
Paper Details
Title
Interactions of ?Ultra-Low? Doses of Naltrexone and Morphine in Mature and Young Male and Female Rats
Published Date
Mar 1, 2004
Journal
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