RNA-guided genetic silencing systems in bacteria and archaea
Abstract
Clustered regularly interspaced short palindromic repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are widespread in bacteria and archaea. Similar to RNA interference (RNAi) pathways in eukaryotes, CRISPR-mediated immune systems rely on small RNAs for sequence-specific detection and silencing of foreign nucleic acids, including viruses and plasmids. However, the mechanism of RNA-based bacterial immunity...
Paper Details
Title
RNA-guided genetic silencing systems in bacteria and archaea
Published Date
Feb 16, 2012
Journal
Volume
482
Issue
7385
Pages
331 - 338
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