Original paper
The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology
Abstract
Clinical manifestations of Plasmodium falciparum infection are induced by the asexual stages of the parasite that develop inside red blood cells (RBCs). Because splenic microcirculatory beds filter out altered RBCs, the spleen can innately clear subpopulations of infected or uninfected RBC modified during falciparum malaria. The spleen appears more protective against severe manifestations of malaria in naïve than in immune subjects. The...
Paper Details
Title
The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology
Published Date
Jan 13, 2011
Journal
Volume
117
Issue
2
Pages
381 - 392
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Notes
History