Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic β -cells

GLUCOSE stimulates insulin secretion from the pancreatic β-cell by increasing the cytosolic calcium concentration1. It is believed that this increment results mainly from Ca2+ influx through dihydropyridine-sensitive calcium channels because insulin secretion is abolished by dihydropyridine antagonists2 and is potentiated by dihydropyridine agonists3. Glucose may influence Ca2+ influx through these channels in two ways: either by regulating the...