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Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides

Published on Feb 1, 2000in Metabolism-clinical and Experimental 6.51
· DOI :10.1016/S0026-0495(00)91377-5
Melania Manco43
Estimated H-index: 43
(CUA: The Catholic University of America),
Av Greco42
Estimated H-index: 42
(CUA: The Catholic University of America)
+ 3 AuthorsGiovanni Gasbarrini85
Estimated H-index: 85
(CUA: The Catholic University of America)
Cite
Abstract
A close relationship between elevated plasma free fatty acid (FFA) levels and insulin resistance is commonly reported in obese subjects. The aim of the present study was to evaluate the role of intramuscular triglyceride (mTG) and FFA levels in insulin sensitivity in 30 nondiabetic normal-weight or obese subjects (18 with body mass index [BMI] = 21.8 ± 3.3 kg/m 2 and 12 with BMI = 34.6 ± 2.7 kg/m 2 ) who underwent minor abdominal surgery. Body composition was estimated by isotopic dilution, substrate oxidation by indirect calorimetry, and whole-body glucose uptake by euglycemic-hyperinsulinemic clamp (EHC). Glucose uptake (M) value negatively correlated with the MTG level ( R 2 = −.56, P v 2.19 ± 0.07, P R 2 = .66, P R 2 = .71, P
  • References (48)
  • Citations (141)
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References48
Newest
Published on Jun 1, 1999in Diabetes 7.20
Geltrude Mingrone49
Estimated H-index: 49
,
Finn Lund Henriksen5
Estimated H-index: 5
+ 7 AuthorsHenning Beck-Nielsen77
Estimated H-index: 77
Raised plasma triglycerides (TGs) and nonesterified fatty acid (NEFA) concentrations are thought to play a role in the pathogenesis of insulin-resistant diabetes. We report on two sisters with extreme hypertriglyceridemia and overt diabetes, in whom surgical normalization of TGs cured the diabetes. In all of the family members (parents, two affected sisters, ages 18 and 15 years, and an 11-year-old unaffected sister), we measured oral glucose tolerance, insulin sensitivity (by the euglycemic-hyp...
90 Citations Source Cite
Published on Jan 11, 1999in Diabetologia 7.11
Martin Krššák34
Estimated H-index: 34
(Yale University),
K. Falk Petersen1
Estimated H-index: 1
(Yale University)
+ 5 AuthorsMichael Roden23
Estimated H-index: 23
(University of Vienna)
Recent muscle biopsy studies have shown a relation between intramuscular lipid content and insulin resistance. The aim of this study was to test this relation in humans by using a novel proton nuclear magnetic resonance (1H NMR) spectroscopy technique, which enables non-invasive and rapid ( ∼ 45 min) determination of intramyocellular lipid (IMCL) content. Normal weight non-diabetic adults (n = 23, age 29 ± 2 years, BMI = 24.1 ± 0.5 kg/m2) were studied using cross-sectional analysis. Insulin sens...
1,036 Citations Source Cite
Agneta Andersson13
Estimated H-index: 13
(Uppsala University),
Anders Sjödin11
Estimated H-index: 11
(Uppsala University)
+ 1 AuthorsBengt Vessby78
Estimated H-index: 78
(Uppsala University)
The effects of low-intensity exercise on the fatty acid composition in skeletal muscle and in serum were studied in 19 sedentary, middle-aged Swedish men. During a 10-wk period, all subjects were given a standardized diet with an identical fat composition. After 4 wk on this diet, they were randomly allocated to a daily exercise program (55% peak oxygen uptake) or to continue to live a sedentary life for the remaining 6 wk. Aerobic capacity (submaximal bicycle test) and peripheral insulin sensit...
98 Citations Source Cite
Published on Jan 9, 1998in Diabetologia 7.11
Pertti Ebeling6
Estimated H-index: 6
(UH: University of Helsinki),
B. Essén-Gustavsson1
Estimated H-index: 1
(SLU: Swedish University of Agricultural Sciences)
+ 1 AuthorsVeikko A. Koivisto52
Estimated H-index: 52
(UH: University of Helsinki)
Increased lipid oxidation is related to insulin resistance. Some of the enhanced lipid utilization may be derived from intramuscular sources. We studied muscle triglyceride (mTG) concentration and its relationship to insulin sensitivity in 10 healthy men (age 29 ± 2 years, BMI 23.3 ± 0.6 kg/m2) and 17 men with insulin-dependent diabetes mellitus (IDDM) (age 30 ± 2 years, BMI 22.8 ± 0.5 kg/m2, diabetes duration 14 ± 2 years, HbA1 c 7.7 ± 0.3 %, insulin dose 48 ± 3 U/day). Insulin sensitivity was ...
41 Citations Source Cite
Published on Oct 1, 1997in Prostaglandins Leukotrienes and Essential Fatty Acids 2.86
Len H. Storlien20
Estimated H-index: 20
(USYD: University of Sydney),
A.D. Kriketos2
Estimated H-index: 2
(USYD: University of Sydney)
+ 2 AuthorsA.B. Jenkins1
Estimated H-index: 1
(USYD: University of Sydney)
Abstract Muscle plays a major role in insulin-stimulated glucose disposal. There is now a range of evidence in humans and experimental animals demonstrating strong relationships between the fatty acid composition of structural membrane lipids and insulin action. The in vivo work is correlative but the in vitro studies suggest a causal relationship exists. Good insulin action is associated with an increased proportion of n-3 fatty acids, low saturates, a low n-6 n-3 ratio and possibly increased m...
70 Citations Source Cite
Kazunori Koyama11
Estimated H-index: 11
(UTSW: University of Texas Southwestern Medical Center),
Guoxun Chen17
Estimated H-index: 17
(UTSW: University of Texas Southwestern Medical Center)
+ 1 AuthorsRoger H Unger112
Estimated H-index: 112
Obesity is associated with both insulin resistance and hyperinsulinemia. Initially hyperinsulinemia compensates for the insulin resistance and thereby maintains normal glucose homeostasis. Obesity is also associated with increased tissue triglyceride (TG) content. To determine whether both insulin resistance and hyperinsulinemia might be secondary to increased tissue TG, we studied correlations between TG content of skeletal muscle, liver, and pancreas and plasma insulin, plasma [insulin] × [glu...
184 Citations Source Cite
Published on Jun 1, 1997in Diabetes 7.20
D. A. Pan4
Estimated H-index: 4
(UOW: University of Wollongong),
Stephen Lillioja34
Estimated H-index: 34
(NIH: National Institutes of Health)
+ 5 AuthorsLeonard H Storlien38
Estimated H-index: 38
(UOW: University of Wollongong)
In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG) correlate with reduced skeletal muscle and whole body insulin action. The aim of this study was to test this relationship in humans. Subjects were 38 nondiabetic male Pima Indians (mean age 28 ± 1 years). Insulin sensitivity at physiological ( M ) and supraphysiological ( MZ ) insulin levels was assessed by the euglycemic clamp. Lipid and carbohydrate oxidation were determined by indirect calorimetry befor...
964 Citations Source Cite
Published on Apr 24, 1997in Diabetologia 7.11
Geltrude Mingrone49
Estimated H-index: 49
(UCSC: Catholic University of the Sacred Heart),
Andrea DeGaetano3
Estimated H-index: 3
(UCSC: Catholic University of the Sacred Heart)
+ 4 AuthorsGiovanni Gasbarrini85
Estimated H-index: 85
(UCSC: Catholic University of the Sacred Heart)
The aim of the present study was to measure whole body glucose uptake (M) and oxidation rate by euglycaemic hyperinsulinaemic clamp and indirect calorimetry in 7 morbidly obese subjects (BMI > 40 kg/m2) at three time points: before bilio-pancreatic diversion (BPD) surgery (Ob); 3 months after surgery (POI); and after reaching stable body weight, at least 2 years after surgery (POII). A group of 7 control subjects (C), matched groupwise for sex, age and BMI with POII patients, was also studied. T...
125 Citations Source Cite
Published on Jan 1, 1997in Diabetes 7.20
Guenther Boden63
Estimated H-index: 63
Evidence is reviewed that free fatty acids (FFAs) are one important link between obesity and insulin resistance and NIDDM. First, plasma FFA levels are elevated in most obese subjects. Second, physiological elevations in plasma FFA concentrations inhibit insulin stimulated peripheral glucose uptake in a dose-dependent manner in normal controls and in patients with NIDDM. Two possible mechanisms are identified: 1 ) a fat-related inhibition of glucose transport or phosphorylation, which appears af...
1,390 Citations Source Cite
Published on Sep 1, 1996in The Lancet 59.10
Giovanni Gasbarrini85
Estimated H-index: 85
(UCSC: Catholic University of the Sacred Heart),
Geltrude Mingrone49
Estimated H-index: 49
(UCSC: Catholic University of the Sacred Heart)
+ 1 AuthorsMarco Castagneto39
Estimated H-index: 39
(UCSC: Catholic University of the Sacred Heart)
The favourable early outcome for this patient indicates that a surgical approach is effective for conditions in which severe hypertriglyceridaemia is present. The patient’s syndrome is linked to a high risk of early atherosclerotic cardiovascular disease. Another important consequence of the operation was the reversibility of insulin-resistant diabetes mellitus. It seems likely that insulin resistance observed in this case was due to the presence of high plasma FFA concentrations involved in Ran...
28 Citations Source Cite
Cited By141
Newest
Published on Mar 7, 2019in Scientific Reports 4.01
Ruriko Suzuki2
Estimated H-index: 2
(Juntendo University),
Yoshifumi Tamura19
Estimated H-index: 19
(Juntendo University)
+ 10 AuthorsYuki Someya7
Estimated H-index: 7
(Juntendo University)
Metabolic clearance rate of insulin (MCRI) is thought to help maintain glucose homeostasis even in healthy subjects. However, the effect of a low carbohydrate/high fat (LCHF) diet on MCRI in healthy subject remains unclear. To investigate the effect of a 3-day eucaloric LCHF diet on MCRI in healthy subjects, we studied 42 healthy non-obese Japanese men. Each subject consumed a eucaloric LCHF diet for 3 days. Before and after the LCHF diet, intramyocellular lipid (IMCL) levels were measured using...
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Published on May 2, 2019in Journal of Lipid Research 4.74
David B. Savage47
Estimated H-index: 47
(University of Cambridge),
Laura Watson (Cambridge University Hospitals NHS Foundation Trust)+ 7 AuthorsAlison Sleigh13
Estimated H-index: 13
(University of Cambridge)
Source Cite
Published on Mar 1, 2019in Aquaculture 3.02
Honghao Zhao1
Estimated H-index: 1
(McGill University),
Othman Soufan5
Estimated H-index: 5
(McGill University)
+ 3 AuthorsDapeng Li8
Estimated H-index: 8
(HAU: Huazhong Agricultural University)
Abstract Grass carp ( Ctenopharyngodon idellus ) is one of the most common aquaculture fish species around the world. High stocking density applied in the intensive C. idellus culture may have negative impact on fish health and flesh quality. To investigate the effect of stocking density on growth, flesh quality, and immune response of C. idellus , we conducted a comprehensive physiological, biochemical, and transcriptome analysis on fish reared at low stocking density (LSD) (5 fish per tank, 2....
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Published on Jan 1, 2019in Journal of Molecular Endocrinology 3.74
Louise K Metcalfe , Greg C. Smith14
Estimated H-index: 14
,
Nigel Turner44
Estimated H-index: 44
Source Cite
Published on Dec 1, 2018in Pathophysiology
Abstract Background Consumption of a high-fat diet (HFD) in aged rats is associated with several metabolic disorders. The mechanism of skeletal muscle lipotoxicity and insulin resistance (IR) is multi-factorial, but the exact mechanism of how aging affects these processes unknown. Royal jelly (RJ) is a dietary supplement with many physiological and pharmacological properties. No previous studies have demonstrated the protective effects and mechanism of RJ in aged obese rats. Objectives The study...
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Published on Jun 1, 2018in Metabolism-clinical and Experimental 6.51
Wei-Sin Yang2
Estimated H-index: 2
(NTU: National Taiwan University),
Pau-Chung Chen41
Estimated H-index: 41
(PRC: China Medical University (PRC))
+ 5 AuthorsKuo-Liong Chien40
Estimated H-index: 40
(NTU: National Taiwan University)
Abstract Background We investigated the association between plasma saturated fatty acids ( SFAs) and the risk of metabolic syndrome among ethnic Chinese adults in Taiwan who attended a health check-up center. Methods A case-control study based on 1000 cases of metabolic syndrome and 1:1 matched control participants (mean age, 54.9 ± 10.7 y; 36% females) were recruited. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation. Gas chromatography was used t...
2 Citations Source Cite
Published on Feb 1, 2018in Magnetic Resonance in Medicine 3.86
Lucas Lindeboom5
Estimated H-index: 5
(UM: Maastricht University),
Robin A. de Graaf40
Estimated H-index: 40
(Yale University)
Purpose Accumulation of triglycerides in nonadipose tissue (e.g. ectopic lipids) is characteristic of metabolic derangements and is linked to insulin resistance and cardiovascular disease. Although the detrimental effects of the total amount of ectopic fat has been established, the role of composition of the ectopic lipid stores is unknown. In this study we used proton magnetic resonance spectroscopy (1H-MRS) homonuclear spectral editing to characterize lipid stores in adipose tissue and skeleta...
2 Citations Source Cite
Published on Apr 1, 2017in Scientific Reports 4.01
Yang Mu3
Estimated H-index: 3
,
Wen-jie Yan5
Estimated H-index: 5
+ 3 AuthorsJing Yang17
Estimated H-index: 17
8 Citations Source Cite
Published on Jan 1, 2017in Endocrinology and Metabolism
Jung Eun Kim27
Estimated H-index: 27
(Purdue University),
Keagan Dunville1
Estimated H-index: 1
(Purdue University)
+ 4 AuthorsWayne W. Campbell39
Estimated H-index: 39
(Purdue University)
5 Citations Source Cite
Published on Sep 15, 2016in PLOS Computational Biology
William B. Ashworth2
Estimated H-index: 2
(UCL: University College London),
Nathan Davies30
Estimated H-index: 30
(UCL: University College London),
Ian David Lockhart Bogle7
Estimated H-index: 7
(UCL: University College London)
In non-alcoholic fatty liver disease (NAFLD), lipid build-up and the resulting damage is known to occur more severely in pericentral cells. Due to the complexity of studying individual regions of the sinusoid, the causes of this zone specificity and its implications on treatment are largely ignored. In this study, a computational model of liver glucose and lipid metabolism is presented which treats the sinusoid as the repeating unit of the liver rather than the single hepatocyte. This allows for...
9 Citations Source Cite