FLT3 Activation Improves Post-Myocardial Infarction Remodeling Involving a Cytoprotective Effect on Cardiomyocytes

The goal of this study was to define the role of FMS-like tyrosine kinase 3 (FLT3) in the heart. FLT3 is a prominent target of receptor tyrosine kinase inhibitors (TKIs) used for anticancer therapy. TKIs can cause cardiomyopathy but understanding of the mechanisms is incomplete, partly because the roles of specific TKI target receptors in the heart are still obscure. Myocardial infarction was induced in mice by permanent ligation of the left...