RNA-guided gene activation by CRISPR-Cas9-based transcription factors
Abstract
Technologies for engineering synthetic transcription factors have enabled many advances in medical and scientific research. In contrast to existing methods based on engineering of DNA-binding proteins, we created a Cas9-based transactivator that is targeted to DNA sequences by guide RNA molecules. Coexpression of this transactivator and combinations of guide RNAs in human cells induced specific expression of endogenous target genes,...
Paper Details
Title
RNA-guided gene activation by CRISPR-Cas9-based transcription factors
Published Date
Oct 1, 2013
Journal
Volume
10
Issue
10
Pages
973 - 976
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