Epigenetic regulation of V(D)J recombination

It has been known for over 25 years from the ground-breaking work of Alt and co-workers that the process of V(D)J recombination is under tight regulation, with each of the V(D)J rearrangement steps creating the heterodimeric antigen receptors occurring in a precise order. In addition, although the same RAG recombinase rearranges TCR and Ig genes, there is strict lineage specificity, other than some IgDH to IgJH rearrangement in thymocytes. After...