Epigenetic regulation of V(D)J recombination
Abstract
It has been known for over 25 years from the ground-breaking work of Alt and co-workers that the process of V(D)J recombination is under tight regulation, with each of the V(D)J rearrangement steps creating the heterodimeric antigen receptors occurring in a precise order. In addition, although the same RAG recombinase rearranges TCR and Ig genes, there is strict lineage specificity, other than some IgDH to IgJH rearrangement in thymocytes. After...
Paper Details
Title
Epigenetic regulation of V(D)J recombination
Published Date
Dec 1, 2010
Journal
Volume
22
Issue
6
Pages
311 - 312
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