419. Generation of Transgene Product-Specific Regulatory CD4+CD25+ T Cells by Hepatic AAV Gene Transfer
Abstract
Top of pageAbstract
Gene therapy for genetic disease may be limited by immune responses to the therapeutic gene product. Previously, we found induction of antigen-specific immune tolerance to secreted transgene products by hepatic AAV gene transfer. Immune tolerance to coagulation factor IX (F.IX) was associated with activation of regulatory CD4+ T cells (Tregs) capable of suppressing antibody formation to F.IX (JCI 111:1347). Experiments in a...
Paper Details
Title
419. Generation of Transgene Product-Specific Regulatory CD4+CD25+ T Cells by Hepatic AAV Gene Transfer
Published Date
May 1, 2005
Journal
Volume
11
Pages
S162 - S163
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