A Zn(II)–glycine complex suppresses UVB-induced melanin production by stimulating metallothionein expression

Synopsis Oxidative stress caused by ultraviolet (UV) radiation generates reactive oxygen species (ROS) in the skin, induces the secretion of melanocyte growth and activating factors from keratinocytes, which results in the formation of cutaneous hyper‐pigmentation. Thus, increasing the anti‐oxidative ability of skin cells is expected to be a good strategy for skin‐lightening cosmetics. Metallothionein (MT) is one of the stress‐induced proteins...