Induction of Nitric Oxide Synthase in Glial Cells
Abstract
Primary astrocyte cultures, C6 glioma cells, and N18 neuroblastoma cells were assayed for nitric oxide synthase (NOS) activity with a bioassay of cyclic GMP production in RFL-6 fibroblasts. Treatment of astrocyte cultures for 16-18 h with lipopolysaccharide (LPS) induced NOS-like activity that was L-arginine and NADPH dependent, Ca2+ independent, and potentiated by superoxide dismutase. Induction was evident after 4 h, was dependent on the dose...
Paper Details
Title
Induction of Nitric Oxide Synthase in Glial Cells
Published Date
Sep 1, 1992
Journal
Volume
59
Issue
3
Pages
897 - 905
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