Study of interactions between titanocene dichloride and mononucleotides by high-resolution 1H- and 31P-nuclear magnetic resonance

The interactions between Cp2TiCl2 and mononucleotides such as 5′-AMP, 5′-CMP, 5′-GMP and 5′-TMP were investigated by high-resolution 1H- and 31P-n.m.r. The results suggest that phosphate (O) and nucleobase (N) are all important targets of Cp2TiCl2. The mechanism of the Cp2TiCl2-DNA interaction is...